Online now: Human primary antibody response to vaccination follows a partially sequential class-switching program with a checkpoint at IGHG2
Online now: HIV tri-specific killer engagers directly enhance NK cell function and safely expand NK cells in vivo
Online now: Toward generalizable prediction of cancer signal using a cell-free DNA language model
Online now: Type I interferon signaling in hematopoietic cells impairs neutrophil antibacterial function in the middle ear during viral co-infection
Online now: STAT3 interference-driven nanomodulators reverse lipid metabolism-associated chemoresistance and potentiate metalloimmunotherapy in breast cancer
Online now: Targeted extracellular vesicle-photoimmunotherapy remodels stromal-immune microenvironment to boost chemo-immunotherapy in preclinical models
Online now: Ion sequential therapy aligned with pathological changes enhances cardiac function after myocardial infarction
Online now: Patient-derived organoids predict personalized drug response and reveal alternative therapeutic options in glioblastoma
Online now: Salmonella vector creates de novo parvovirus that reduces solid tumors and forms antitumor immune memory
Online now: Metabolically engineered probiotic OMVs as nanovaccine mediating sequential immunomodulation for chronic bone infection immunotherapy
Cell Reports Medicine
Cell Reports Medicine
Cell Reports Medicine
Cell Reports Medicine
Cell Reports Medicine
Cell Reports Medicine
Cell Reports Medicine
Cell Reports Medicine
Cell Reports Medicine
Cell Reports Medicine
Xu et al. analyze patterns in cell-free DNA fragments to detect cancer signals from very low sequencing input across cancer types and clinical settings. The approach supports early detection, treatment monitoring, and post-treatment risk assessment while reducing sequencing demands across assay types.
dlvr.it
Khanduja et al. demonstrate that virus-delivering Salmonella (VDS) carries the H-1 parvovirus genome directly into cancer cells, enabling de novo virion formation, potent tumor regression, and durable antitumor immunity. VDS overcomes systemic OV delivery barriers, reshapes the tumor microenvironment, and generates tumor-specific immune memory that prevents re-implantation.
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Shaw et al. investigate how immune modulation by viruses worsens bacterial infection in the middle ear, the most common site of childhood infection. In a pathway distinct from lung co-infections, virus induction of a type I interferon response targets myeloid cells, impairing middle ear neutrophil antibacterial function.
Lei et al. screen Lactococcus lactis OMVs (Lac-OMVs) and develop a metabolically engineered NAD+-Lac-OMV nanovaccine with potent tissue-repair therapeutic effects. NAD+-Lac-OMVs sequentially activate dendritic cells by membrane components and reprogram inflammatory macrophages for anti-inflammation and bone repair by interior nicotinamide metabolites.
dlvr.it
HIV remains a health issue, with new therapies needed. Cromarty et al. show that HIV tri-specific killer engagers bind to and mediate effective NK cell functions against HIV-infected cells. In rhesus macaques, HIV TriKEs expand and activate the NK cell population, similar to other licensed IL-15-containing agents.
Using the SARS-CoV-2 mRNA vaccine as a model immune challenge, Montamat-Garcia et al. describe how antibody class-switch recombination (CSR) during a primary human response is partially sequential, but with checkpoint at the IGHG2 locus. Moreover, CSR is influenced by the B cell subset and VDJ gene usage.
Solid tumors develop dense stromal barriers that limit drug delivery and immune attack. Qu et al. engineer MDK-targeted EV carrying a photosensitizer that, upon light activation, simultaneously reprograms the CAFs and immune microenvironment. This dual stromal-immune remodeling markedly enhances the efficacy of immunotherapy and chemotherapy in preclinical models.
dlvr.it
Park et al. show that patient-derived glioblastoma organoids faithfully recapitulate parental tumor features and predict clinical responses to temozolomide more accurately than current biomarkers, including MGMT status. This platform reveals heterogeneous resistance mechanisms and enables personalized drug screening, identifying lazertinib as a promising therapeutic option for temozolomide-resistant glioblastoma.
Zhong et al. map the spatiotemporal dynamics of zinc and copper following myocardial infarction. They develop a sequential Zn-Cu therapy, delivered via an epicardial device, that matches physiological needs. This targeted approach enhances cardiac repair and improves ventricular function by regulating the circadian gene PER2.
dlvr.it
Pei et al. develop an activable nanoplatform NiS@ALB for co-delivery of Ni2+ and H2S to initiate metalloimmunotherapy and modulate STAT3 signaling-mediated lipid metabolism, which synergistically potentiates the chemosensitivity and immunogenicity of breast cancer. The combination with chemotherapy and αPD-1 elicits potent systemic immune response and suppresses breast tumor progression and metastasis.
