Online now: Type I interferon signaling in hematopoietic cells impairs neutrophil antibacterial function in the middle ear during viral co-infection
Shaw et al. investigate how immune modulation by viruses worsens bacterial infection in the middle ear, the most common site of childhood infection. In a pathway distinct from lung co-infections, virus induction of a type I interferon response targets myeloid cells, impairing middle ear neutrophil antibacterial function.
