Online now: Ion sequential therapy aligned with pathological changes enhances cardiac function after myocardial infarction
Zhong et al. map the spatiotemporal dynamics of zinc and copper following myocardial infarction. They develop a sequential Zn-Cu therapy, delivered via an epicardial device, that matches physiological needs. This targeted approach enhances cardiac repair and improves ventricular function by regulating the circadian gene PER2.