Happy to share the first research article of our team. We report that foreign DNA, such as ISD, activates DNA damage signaling mainly through DNA-PK.
@ircan.bsky.social @univcotedazur.bsky.social @cnrsbiologie.bsky.social @canceropolesud.bsky.social
www.jbc.org/article/S002...
Are you interested in achieving efficient silencing of transposable elements using CRISPRi? 🧬 🧫
Go ahead and have a look at this STAR protocols where Adami et al. share all the tips & tricks they use in the Jakobsson lab.
@anitaada.bsky.social @raquelgarza.bsky.social @jakobssonlab.bsky.social
Here, we present a workflow for transcriptional silencing of transposable elements
(TEs) in human induced pluripotent stem cells (hiPSCs). We describe steps for designing
guide RNAs (gRNAs) to target ...
www.cell.com
www.jbc.org
In eukaryotic cells, DNA is normally confined in the nucleus and mitochondria and
the presence of DNA in the cytoplasm is a danger signal that activates innate immune
responses. Upon detection of cyto...
Excited to share our Nature Genetics Research Briefing on how the repetitive genome helps shape leukemia stemness.
We found that transposable elements sustain stem-like states in AML and predict patient outcomes.
www.nature.com/articles/s41...
