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Happy to share the first research article of our team. We report that foreign DNA, such as ISD, activates DNA damage signaling mainly through DNA-PK. @ircan.bsky.social @univcotedazur.bsky.social @cnrsbiologie.bsky.social @canceropolesud.bsky.social www.jbc.org/article/S002...
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In eukaryotic cells, DNA is normally confined in the nucleus and mitochondria and the presence of DNA in the cytoplasm is a danger signal that activates innate immune responses. Upon detection of cyto...
www.jbc.org
Interferon Stimulatory DNA activates the DNA damage signaling through ATM and DNA-PK sensing
Hervé (rv) Técher