Agnete Kirkeby’s 2025 Edinburgh Parkinson’s Lecture is available online: youtu.be/EtuRHdPX4rc?...
She delivered a masterclass on stem cell therapies for #Parkinsons. A PwP told me : “I was expecting not to understand much, but I understood everything!” @kirkebylab.bsky.social @parkinsons.org.uk
Always a joy to join #EMBOMobileGenome -A week full of cool nature’s quirks and science along the friendliest crowd 🧬 Happy to have shared our work on ERVs in human brain evolution (talk by @jakobssonlab.bsky.social) and Parkinson’s disease (poster by yours truly) 🧠
#ASAP @jakobssonasap.bsky.social
Excited to share that our team is joining ASAP CRN @asapresearch.parkinsonsroadmap.org! We look forward to collaborating with scientists globally to catalyze breakthroughs in Parkinson’s & accelerate discoveries that lead to new treatments.
Explore more: asapcrn.org #ParkinsonsDisease
CRN Teams Cragg & Jakobsson's new #preprint maps the cell-type–specific transcriptional landscape of the parkinsonian striatum in mouse models and human Parkinson's stages, revealing widespread gene expression changes and resilient neuron subtypes amid progressive dopamine loss 🧪
🔗 bit.ly/4ju4MmS
📣 New preprint from the Jakobsson lab!
We describe a detailed protocol to inhibit the expression of transposable elements in human pluripotent stem cells, developed thanks to @asapresearch.parkinsonsroadmap.org funding.
Special shoutout to @anitaada.bsky.social!
www.biorxiv.org/content/10.1...
Have a look at the new preprint from Team Cragg! We are very happy of having contributed to this great work as a collaboration within the ASAP-CRN network 🧠🔬
@craggasap.bsky.social @asapresearch.parkinsonsroadmap.org
The Barker Lab
@raquelgarza.bsky.social from the Jakobsson Lab presented our recent work on single-cell omics (transcriptomics+ proteomics) within our ASAP project at the SciLifeLab Lund day. This work is being done in collaboration with #BioMS and @scilifelab.se. We are looking forward to the discoveries ahead 🌟
This protocol describes the workflow for transcriptional silencing of transposable elements (TEs) in human induced pluripotent stem cells (hiPSCs). The protocol illustrates how to design gRNAs to targ...
🚨 Have a look at our new preprint: www.biorxiv.org/content/10.1...
A highly collaborative effort where we show that transposable elements are directly linked to a cell-type and region specific inflammatory state in Parkinson’s Disease.
@asapresearch.parkinsonsroadmap.org
www.cell.com
Here, we present a workflow for transcriptional silencing of transposable elements
(TEs) in human induced pluripotent stem cells (hiPSCs). We describe steps for designing
guide RNAs (gRNAs) to target ...
Parkinson's disease (PD) is a common age-related neurodegenerative disorder involving a neuroinflammatory response, the cause of which remains unclear. Transposable elements (TE) have been linked to i...
New #publication and #preprint from @jakobssonasap.bsky.social!
⬅️ L1 retrotransposons in stem cells & organoids link L1s to CNS development 🔗 bit.ly/3XyLvGz
➡️ Transposable elements activate in the #Parkinsons brain, tied to interferon responses & a new pathological process 🔗 bit.ly/3LKC5Fo
📣 New preprint alert 📣
A new collaborative study from @meletis.bsky.social and @jakobssonasap.bsky.social on mapping the molecular changes in the mouse and human striatum in #Parkinsons! Congratulations to Marta Graziano and Ioannis Mantas for spearheading this fantastic work!
#OpenScience
💥 New preprint! 💥
We show that transposons are directly linked to a cell-type and region specific inflammatory state in Parkinson’s Disease 🧠🦠
What a team @jakobssonasap.bsky.social! Funded by @asapresearch.parkinsonsroadmap.org
#Parkinsons #Neuroinflammation #TEworldwide #singlecell #TEs
The progressive degeneration of dopaminergic projections to the striatum is a key disease mechanism in Parkinson's disease (PD). To define the cellular landscape in the parkinsonian striatum, we mappe...
