Happy to share the first research article of our team. We report that foreign DNA, such as ISD, activates DNA damage signaling mainly through DNA-PK.
@ircan.bsky.social @univcotedazur.bsky.social @cnrsbiologie.bsky.social @canceropolesud.bsky.social
www.jbc.org/article/S002...
Key findings:
1️⃣ L1s drive large-scale rearrangements including translocations (not just insertions)
2️⃣ Frequency of these events was largely underestimated by short-reads
3️⃣ They occur EARLY, thus potentially acting as drivers
#Genomics #CancerResearch #MobileDNA @nanoporetech.com