🔄 #Enzymes can adopt multiple #conformations.
⚡ Some of these act as functional sub-states.
📚 We summarised recent studies, the methods used to uncover these hidden states, and the challenges ahead in linking them to #proteinevolution.
www.sciencedirect.com/science/arti...
Zeynep Baharoglu
Is it too early for a year review? 🤔
Research stays at ETH Zürich with Adrian Bunzel and at UBC Vancouver with Nobu 🤓.
Now I’m moving labs to start as Associate Professor at UiT, which means organising freezer contents 📦.
Two β-lactamase evolution preprints coming soon 🧬.
Stay tuned!
Living in the Arctic 🥶 means Christmas comes early 🎁🥳
10 MNOK (≈1 MUSD) Early Career Investigator grant from the Research Council of Norway to work with the fabulous @bunzela.bsky.social (Max Planck Institute) on uncovering the molecular mechanisms of antibiotic resistance.
#AMR #beta-lactamases
Christopher Frøhlich
Abstract. Sense codon reassignment enables ribosomal incorporation of nonproteinogenic amino acids (npAAs) at any of the 61 sense codons. Because npAAs rep
Sometimes, adaptation to one #antibiotics can make bacteria more vulnerable to other drugs. #CollateralSensitivity.
💡 By following the evolution of a β-lactamase, we uncovered how mutations can both create and mitigate such collateral sensitivity networks.
www.biorxiv.org/content/10.6...
Looking for a PostDoc in molecular biology and structural biology ?
Check out the position in my group:
www.jobbnorge.no/en/available...
🚨PREPRINT🚨
Enzyme function does not rely only on static structure 🧩, but also on the rate at which functional sub-states interconvert ⏱️, making this interconversion subject to natural selection 🧬.
#OXA-48 #ceftazidime #enzymeevolution
www.biorxiv.org/content/10.6...
We studied the causes of #collateralsensitivity from a single enzyme perspective using and how stable such #tradeoffs are during #coselection.
In short, resistance evolution can cause strong but migigatable trade-offs.
Preproof is now available on @JMB:
www.sciencedirect.com/science/arti...
Christopher Frøhlich
Christopher Frøhlich
Interested in #β-lactamase inhibitors? 🧪
Our new #mSphere paper shows how a covalent boronic-acid + chelator fusion ⚗️ can restore β-lactam susceptibility in metallo-β-lactamase producers, even in variants that are difficult to inhibit with #taniborbactam.
journals.asm.org/doi/full/10....
Christopher Frøhlich
As antibiotic discovery stalls, exploiting collateral sensitivity, where resistance to one drug increases sensitivity to another, offers a promising r…
