Living in the Arctic 🥶 means Christmas comes early 🎁🥳
10 MNOK (≈1 MUSD) Early Career Investigator grant from the Research Council of Norway to work with the fabulous @bunzela.bsky.social (Max Planck Institute) on uncovering the molecular mechanisms of antibiotic resistance.
#AMR #beta-lactamases
doi.org
🚨PREPRINT🚨
Enzyme function does not rely only on static structure 🧩, but also on the rate at which functional sub-states interconvert ⏱️, making this interconversion subject to natural selection 🧬.
#OXA-48 #ceftazidime #enzymeevolution
www.biorxiv.org/content/10.6...
Abstract. Sense codon reassignment enables ribosomal incorporation of nonproteinogenic amino acids (npAAs) at any of the 61 sense codons. Because npAAs rep