🚨PREPRINT🚨
Enzyme function does not rely only on static structure 🧩, but also on the rate at which functional sub-states interconvert ⏱️, making this interconversion subject to natural selection 🧬.
#OXA-48 #ceftazidime #enzymeevolution
www.biorxiv.org/content/10.6...
www.biorxiv.org
Enzymes do not operate as static structures, but continuously fluctuate between different conformations. Enzymes therefore dynamically sample conformations with varying catalytic activity. However, it...
