We studied the causes of #collateralsensitivity from a single enzyme perspective using and how stable such #tradeoffs are during #coselection.
In short, resistance evolution can cause strong but migigatable trade-offs.
Preproof is now available on @JMB:
www.sciencedirect.com/science/arti...
As antibiotic discovery stalls, exploiting collateral sensitivity, where resistance to one drug increases sensitivity to another, offers a promising r…
