🎉 In the final round of the ExStra Program of the DFG, the CPI has been selected & is honored with funding for another 7 years! 🏆 With the vision that “precision biology drives precision medicine”, funds will be used for high-risk, innovative research for cardiopulmonary health ❤️🫁!
🗺️ Interactive Map Update!
The Münch Lab @cmunch.bsky.social has joined the global TPD map! 🎉
Explore their work and discover other labs studying #TPD and #ubiquitin biology.
👉 tpd-community.com
#ProteinDegradation
Rupert Beale @bealelab.bsky.social and co-workers @crick.ac.uk @imperialcollegeldn.bsky.social show that #caspase cleavage of #influenza A #virus M2 disrupts M2-LC3 interaction and regulates virion production.
-> www.embopress.org/doi/full/10....
I am overjoyed to present our latest paper on Autophagy in CD8 Tcells!
www.nature.com/articles/s41...
It was, as all ‘sciencing’ is, a huge team effort.
I will try to do it some justice in the following thread 😊 1/n
@cantrell-lab.bsky.social @immpres.bsky.social @ajmhowden.bsky.social
Fantastic work and important inside into a longstanding question!
Have a look at our newest commentary in @pnas.org :
"G-quadruplexes and their unexpected ability to fold proteins"
Full text: www.pnas.org/doi/10.1073/...
#G4 #quadruplex #proteins #folding
How do cells cope with stress?
Explore the molecuar details of cellular stress responses in Prof. Christian Münch’s group(@cmunch.bsky.social, @goetheuni.bsky.social). All details and the application portal are available on our website:👉 imprs-cbp.mpg.de/call-for-app... #phd #biophysics #cellbiology
Super excited to share our latest work on deciphering the #Ubiquitin Code
“𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀”
@cp-molcell.bsky.social
1/8
www.cell.com/molecular-ce...
Less than a week left to apply to the open post doc position in our lab. Join us in beautiful Gothenburg to work on an exciting project!
www.nature.com/naturecareer...
Targeted protein degradation community
Cardio-Pulmonary Institute | CPI
Sinclair et al. combine quantitative proteomics and an autophagy flux reporter to map autophagy substrates and triggers during CD8 T cell differentiation. Proteins degraded and fueled by autophagy in ...
Ubiquitin chains determine the fates of their modified proteins, including proteasomal
degradation. Kiss et al. present UbiREAD, a technology to monitor cellular degradation
and deubiquitination at hi...
www.cell.com
Investigating the molecular connectivity of mitochondrial gene expression, protein biogenesis and quality control Background: Mitochondria convert ...
🎉 We’re absolutely thrilled: SCALE has been selected as a DFG Excellence Cluster!
A huge thank you to our incredible team—this would not have been possible without your dedication and talent. 🙌 @dfg.de
#ClustersOfExcellence #SCALEcluster 🧵
Christian Münch
Schwalbe Lab
Leo Kiss
IMPRS on Cellular Biophysics
Martin Ott lab
Exciting news from the lab out today in Science - the structure of human PINK1 on a TOM-VDAC complex!
@wehi-research.bsky.social
SCALE - SubCellular Architecture of LifE
Komander Lab
Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...
@wehi-research.bsky.social @komanderlab.bsky.social
