Molecular glue degraders don't just block proteins; they reprogram cellular recognition logic to eliminate "undruggable" targets entirely.
Clues for Glues review by @zkozicka.bsky.social
doi.org/10.1042/EBC2...
ā³There is less than ONE WEEK to go until our #UbiquitinFunction registration deadline (Tuesday 07 April)
šāāļøDonāt miss your opportunity to register & connect with industry experts, discover fresh insights, & network with like-minded professionals.
šļø Register now before itās too late!
bit.ly/3OQhXTY
Join us for the #Ubiquitin & Friends Symposium 2026, April 29-30, in Vienna!
Fantastic guest speakersš & many slots for talks from abstracts, flash-talks & posters. Lots of opportunities to network. Register now to save your spot!
ā”ļø www.protein-degradation.org/symposium/
#ubfriends2026
The E3 ubiquitin ligase mechanism specifying target-directed microRNA degradation (TDMD) is now published! šš¾ We, @bartellab.bsky.social and Schulman lab, describe how 2-RNA factors control protein degradation by recruiting an E3 ligase. @mpibiochem.bsky.social
www.nature.com/articles/s41...
Good morning!! This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: Systems-level organization of extracellular proteostasis www.science.org/doi/10.1126/...
Excited to share our latest study on how K29/K48-branched #ubiquitin chains are forged by the #E3 ligase TRIP12, and how this suggests a consensus mechanism for chain formation by HECT E3s!
@natsmb.nature.com
1/7
www.nature.com/articles/s41...
š Fantastic talk by Professor Craig Crews @craigmcrews.bsky.social at the Lund Spring Symposium on the past and future of PROTACs!
š Congratulations on receiving The Special Achievement Award ā well-deserved recognition for major contributions to TPD!
#TPD #PROTAC #LundSpringSymposium
1 week to go! WĆ¼rzburg's ready - are You? The GRK2243 Symposium 2025 is just around the corner. Pack your bags, prep your slides, and get hyped!
#wUeBI2025
Registration now open! 2026 #EMBO #Ubiquitin Workshop set in stunning Monopoli, Puglia š®š¹
Cutting edge science, great speakers, short talk opportunities, travel awards
Limited spaces. Dont miss out - register early!
Registration & more info: meetings.embo.org/event/26-ubi...
šŗļø Interactive Map Update!
2 new UK-based labs have been added to the global TPD map:
š¹ Kessler Lab @kesslerbenedikt001.bsky.social
š¹ Fletcher Lab
Explore these and many other TPD and ubiquitin labs:
š tpd-community.com
#TPD #ProteinDegradation #Ubiquitin
biomed.news
Using biochemistry, chemical biology, and cryo-EM, Maiwald et al. elucidate how TRIP12 forms K29 linkages and K29/K48-linked branched ubiquitin chains, revealing a mechanism for polyubiquitylation sha...
