Interesting back-to-back papers from the Varani Group in @narjournal.bsky.social showing that an approved kinase inhibitor can specifically bind the HIV-1 TAR RNA element and influence its downstream function. A promising direction!
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
academic.oup.com
Abstract. We report that the kinase inhibitor Palbociclib is a very low nanomolar ligand for the HIV-1 TAR, a paradigmatic ‘difficult-to-drug’ RNA. Binding
Excited to see this work out in @narjournal.bsky.social!
Our collaborators @weigandlab.bsky.social dissect how SARS-CoV-2 5'-UTR RNA structures and nsp1 protein variants co-evolve to control viral translation. We were glad to contribute to parts of this project!
academic.oup.com/nar/article/...
Our recent publication exploring how complexity and “emergence” in chemistry may help explain the transition from non-living to living matter is now featured in a press release by Goethe University Frankfurt!
Press release: www.uni-frankfurt.de/press-releas...
Publication: doi.org/10.1002/anie...
Check out the new article: "Moving NMR infrastructures to remote access capabilities":
www.sciencedirect.com/science/arti...
#NMR #remote #datamanagement
New publication alert from our lab 💥☺️
"Integrated NMR/MD investigation reveals differences after reweighting in conformational ensembles of GAAG and GCAA tetraloops"
Full text: rnajournal.cshlp.org/content/earl...
#NMR #MD #RNA
Excited to share that our project (smART) has received funding approval from the German Research Foundation (DFG) as part of the latest funding round.
We’re grateful for the support and looking forward to the next phase of exciting RNA research! 🥳
www.dfg.de/de/aktuelles...
#Research #Funding #DFG
Also congrats to the other Goethe initiatives receiving further funding by the DFG! Strong recognition for Frankfurt research across mRNA biology, connective tissue, and protein complexes.
www.uni-frankfurt.de/en/newsroom/...
Abstract. Several SARS-CoV-2 variants have evolved with clinical relevance due to their structural and functional impact on viral proteins and genomic RNA
A new publication on G4s is online 💥
"Dissecting the Chemical and Thermal Stabilities of Tetrads in G-Quadruplexes to Derive a Structure-Activity Relation for a Thrombin-Binding DNA G-Quadruplex Aptamer"
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
#G4 #quadruplex #NMR
Traditionally, Nuclear Magnetic Resonance (NMR) infrastructures have relied on in-person access, requiring researchers to travel to centralized facili…
New CRC/TRR 440 smART Develops mRNA Tools – Collaborative Research Centres 1507 and 1531 of the Rhine-Main Universities (RMU) on Cellular Supercomplexes and...
www.uni-frankfurt.de
A monthly journal publishing high-quality, peer-reviewed research on all topics related to RNA and its metabolism in all organisms
Die #DFG fördert zur weiteren Stärkung der #Spitzenforschung an den Hochschulen 13 neue #Sonderforschungsbereiche (SFB). Die Themen reichen von der Erforschung extraterrestrischen Lebens bis zu Papieranwendungen der Zukunft. Einzelheiten 👉 www.dfg.de/de/aktuelles/…
First talk by our director Prof Schwalbe @schwalbe-lab.bsky.social
This conference is the opportunity to showcase integrated structural biology, we are now in our 7th edition. Tomorrow we will announce which Instruct country is hosting next!
Read more here instruct-eric.org/ibsbc2026
Schwalbe Lab
Schwalbe Lab
Schwalbe Lab
Schwalbe Lab
Extended variants of the G-quadruplex thrombin binding aptamer exhibit differential anticoagulation activities. We show that 3’ terminal extensions increase nuclease resistance, while variations in t....
Instruct-ERIC is a pan-European research infrastructure in structural biology, making high-end technologies and methods available to all European researchers.
The @instruct-eric.bsky.social Biennial Structural Biology Conference #IBSBC2026 is underway today in Brussels
Thanks to our hosts @jansteyaert.bsky.social and his team at the highly successful #Nanobodies4Instruct facility
Learn all about is and apply to access instruct-eric.org
