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A new publication on G4s is online 💥 "Dissecting the Chemical and Thermal Stabilities of Tetrads in G-Quadruplexes to Derive a Structure-Activity Relation for a Thrombin-Binding DNA G-Quadruplex Aptamer" chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/... #G4 #quadruplex #NMR
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Extended variants of the G-quadruplex thrombin binding aptamer exhibit differential anticoagulation activities. We show that 3’ terminal extensions increase nuclease resistance, while variations in t....
chemistry-europe.onlinelibrary.wiley.com
Dissecting the Chemical and Thermal Stabilities of Tetrads in G‐Quadruplexes to Derive a Structure‐Activity Relation for a Thrombin‐Binding DNA G‐Quadruplex Aptamer
Schwalbe Lab