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Interesting back-to-back papers from the Varani Group in @narjournal.bsky.social showing that an approved kinase inhibitor can specifically bind the HIV-1 TAR RNA element and influence its downstream function. A promising direction! academic.oup.com/nar/article/... academic.oup.com/nar/article/...
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Abstract. We report that the kinase inhibitor Palbociclib is a very low nanomolar ligand for the HIV-1 TAR, a paradigmatic ‘difficult-to-drug’ RNA. Binding
academic.oup.com
The kinase inhibitor palbociclib binds to HIV TAR RNA with very low nanomolar affinity and exquisite specificity
Schwalbe Lab