PI @uam-ibmib.bsky.social, developmental epigenetics, 3D nuclear architecture, prev postdoc @bostonu.bsky.social & @ox.ac.uk 🇵🇱 🇪🇺 #StandWithUkraine 🇺🇦 https://ibmib.web.amu.edu.pl/groups/developmental-epigenetics-research-group/
Michal Gdula
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New week, insights! ✨ The team led by Kinga Kamieniarz-Gdula (@stoplab.bsky.social) reveals in EMBO Reports how SETD2 acts as a genetic "traffic controller." A vital step in understanding cancer biology!
Congrats to @michal-gdula.bsky.social, @agatakstepien.bsky.social, @mgkopczynska.bsky.social! 👏
Non-Mendelian inheritance of DNA methylation patterns in mice www.nature.com/articles/s41...
Great news! 🥳 Dr. Anna Baud with Prof. Krzysztof Sobczak showed that insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) positively regulates the noncanonical translation of expanded CGG repeats and may be a promising target for clinical applications. Published in Nature Communications!
Great news! 🥳 A new study from the group of @piotraz.bsky.social shows that it is possible to precisely control where meiotic recombination occurs in plant genomes using the CRISPR/dCas9 system. Now published in Science Advances! Congratulations Maja Szymańska-Lejman, Piotr Ziolkowski and the crew!
Big news! 🥳 Joanna Szpotkowska, together with Prof. Malgorzata Borowiak, presents Glutathione Peroxidase 2 as a critical regulator of human posterior foregut differentiation, revealing oxidative stress as a key determinant of pancreatic versus non-pancreatic cell fate. Now in Nature Communications!
SETD2 is a methyltransferase responsible for depositing histone H3 lysine 36 trimethylation (H3K36me3). Loss of its enzymatic activity occurs in some cancers, including renal cell carcinoma. SETD2 mut...
Davidovich et al. investigate allele-specific DNA methylation inheritance patterns in mouse liver and muscle. Most patterns are Mendelian, but ~7% are non-Mendelian, including new imprinted genes and ...
www.nature.com
Expanded FMR1 CGG repeats drive toxic FMRpolyG in premutation disorders. Here, the authors show that IGF2BP3 binds the FMR1 5’UTR to promote non-AUG translation of FMRpolyG and that its loss reduces t...
Exciting #CtrlEpiEdit conference update: Maja Jagodic @ki.se will be joining us in Paris! Check out her fantastic in vivo epigenome editing preprint here: www.biorxiv.org/content/10.6...
And register for the symposium here 😉: ctrlepiedit.sciencesconf.org
Please repost!
Tread -1- EpiSci - I am very proud to share with you our new study that you can access on @biorxivpreprint.bsky.social (see link below)
"The Interaction with Nanotopographical Environment regulates nuclear mechanoresponse in mESCs via Histone Demethylase KDM3A.
www.biorxiv.org/content/10.6...
The role of metabolic processes in endoderm differentiation remains elusive. Here, the authors discover that oxidative stress and GPX2 determine whether human stem cells differentiate into pancreatic ...
A strong hint from human genetics that changes in DNA methylation may be causal for normal aging. This is the direction that aging (and cancer) research needs to go!
www.nature.com/articles/s41...
Are you a DNMT3 enthusiast wondering how they achieve specificity at CpG islands during development? And why is DNMT3B specifically required for methylation on the inactive X?
We set out to dissect the mechanism, now published in Genes & Development
genesdev.cshlp.org/content/earl...
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Exciting work! The authors conclude that condensin-mediated loop formation, Aurora B phosphorylation, and core histone deacetylation are not obligatory factors for mitotic chromosome compaction.
Our Mg2+ model is discussed as the “last model standing.”
www.cell.com/current-biol...
Maxim Greenberg
Carmelo Ferrai
www.nature.com
This study investigates the consequences of hypermethylation in a progeria syndrome caused by gain-of-function DNMT3A mutations, finding effects on adult stem cell function.
How the negatively charged long genomic DNA is organized into mitotic chromosome remains
unclear. Using a newly developed Mg2+ indicator, Maeshima et al. demonstrate a transient
rise in free Mg2+ rele...
Online Now: A time-resolved atlas of histone modifications during mitotic entry Online now:
DNA is wrapped around histones, forming chromatin, which becomes more compact during mitosis. Kochanova et al. elucidate the complex landscape of histone post-translational modifications upon mitotic chromosome formation and discover that H3T3ph is restricted to chromatin with silent genes and that acetylation is only mildly decreased as chromosomes form.
