Exciting work! The authors conclude that condensin-mediated loop formation, Aurora B phosphorylation, and core histone deacetylation are not obligatory factors for mitotic chromosome compaction.
Our Mg2+ model is discussed as the “last model standing.”
www.cell.com/current-biol...
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How the negatively charged long genomic DNA is organized into mitotic chromosome remains
unclear. Using a newly developed Mg2+ indicator, Maeshima et al. demonstrate a transient
rise in free Mg2+ rele...
Online Now: A time-resolved atlas of histone modifications during mitotic entry Online now:
DNA is wrapped around histones, forming chromatin, which becomes more compact during mitosis. Kochanova et al. elucidate the complex landscape of histone post-translational modifications upon mitotic chromosome formation and discover that H3T3ph is restricted to chromatin with silent genes and that acetylation is only mildly decreased as chromosomes form.
