#Chromatin biologist/biophysicist @nigidenken.bsky.social & SOKENDAI in Japan. Chromatin is very dynamic and flexible, but NOT regular!!! 🧪🧬🔬
My career and work: http://bit.ly/2CuF4L5
Lab HP: https://bit.ly/3F1a8nk
YouTube Seminar: https://bit.ly/4fYZiOj
Kazuhiro Maeshima
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“I think it’s a real mistake to forget where the pipeline for all this begins.”
John Diffley reflects on the importance of basic research, his mission to decode DNA replication and recreate it in the lab, and the scientific optimism of the 1960s that helped shape it.
www.crick.ac.uk/news/2026-03...
My Fragile Nucleosome seminar is now on YouTube
www.youtube.com/watch?v=ksXp...
I discuss our recent work showing that linker histone H1 behaves as a liquid-like glue for chromatin organization in living human cells 🧬
Paper:
www.science.org/doi/full/10....
Huge thanks to @fnucleosome.bsky.social!
Out now in Science! Our study challenges long-standing assumptions about transcription factor specificity in eukaryotes. Novel single-molecule measurements of TF behavior in living cells reveal an independence of locus-specific binding from DNA sequence recognition.🧵
www.science.org/doi/10.1126/...
Beautiful view of Earth from space taken from the International Space Station.
New preprint from our lab! We've been working out how the CMG replicative helicase gets built. 🧵 1/3
