My Fragile Nucleosome seminar is now on YouTube
www.youtube.com/watch?v=ksXp...
I discuss our recent work showing that linker histone H1 behaves as a liquid-like glue for chromatin organization in living human cells 🧬
Paper:
www.science.org/doi/full/10....
Huge thanks to @fnucleosome.bsky.social!
Our new preprint! 🧬✨ www.biorxiv.org/cgi/content/...
@ynagata.bsky.social et al. combined single-nucleosome imaging with Fucci probes to follow local chromatin behavior during interphase. Local nucleosome motion stays nearly constant from G1 to G2, except in early G1. Thanks to all coauthors!
Local nucleosome motion is increased by transcription inhibition, replication stress, or DNA damage, suggesting that chromatin motion is near-constant but tunable during interphase. 🧬🔬✨
See also our previous #ScienceAdvances paper by @shiori-iida.bsky.social :
www.science.org/doi/full/10....
“I think it’s a real mistake to forget where the pipeline for all this begins.”
John Diffley reflects on the importance of basic research, his mission to decode DNA replication and recreate it in the lab, and the scientific optimism of the 1960s that helped shape it.
www.crick.ac.uk/news/2026-03...
Video
Beautiful view of Earth from space taken from the International Space Station.
The Francis Crick Institute
Video
Exciting work! The authors conclude that condensin-mediated loop formation, Aurora B phosphorylation, and core histone deacetylation are not obligatory factors for mitotic chromosome compaction.
Our Mg2+ model is discussed as the “last model standing.”
www.cell.com/current-biol...
How the negatively charged long genomic DNA is organized into mitotic chromosome remains
unclear. Using a newly developed Mg2+ indicator, Maeshima et al. demonstrate a transient
rise in free Mg2+ rele...
www.cell.com
Wonder of Science
Out now in Science! Our study challenges long-standing assumptions about transcription factor specificity in eukaryotes. Novel single-molecule measurements of TF behavior in living cells reveal an independence of locus-specific binding from DNA sequence recognition.🧵
www.science.org/doi/10.1126/...
www.science.org
How intrinsically disordered regions (IDRs) shape chromatin binding and nuclear organization of transcription factors (TFs) remains unclear. We used proximity-assisted photoactivation (PAPA), a single...
