Great news! 🥳 Dr. Anna Baud with Prof. Krzysztof Sobczak showed that insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) positively regulates the noncanonical translation of expanded CGG repeats and may be a promising target for clinical applications. Published in Nature Communications!
Expanded FMR1 CGG repeats drive toxic FMRpolyG in premutation disorders. Here, the authors show that IGF2BP3 binds the FMR1 5’UTR to promote non-AUG translation of FMRpolyG and that its loss reduces t...
