Happy to share the latest macrocycle paper from the Heinis lab, which I was happy to play a small part in during my postdoc. Big congrats to co-first authors Xinjian and Lluc. Now out in @natchembio.nature.com
www.nature.com/articles/s41...
Membrane-permeable cyclic peptides offer access to difficult intracellular targets but discovery remains challenging. Here the authors show that cell-active cyclic peptides can be identified by screen...
Structures of telomerase with allosteric inhibitor BIBR1532 reveal an unexpected mode of inhibition and unique insights into telomerase mechanism
www.nature.com/articles/s41...
Telomerase, the ribonucleoprotein that maintains telomere ends, is upregulated in most cancer cells, making it a promising oncology target. Cryo-electron microscopy structures of telomerase with allos...
The editorial highlights RNA breakthroughs in this issue
www.nature.com/articles/s41...
and a Q&A with Maria Duca, Samie Jaffrey, and Ling-Ling Chen discusses challenges and opportunities in RNA-centered therapeutics
www.nature.com/articles/s41...
A new Perspective details the current bottlenecks and outlines a research roadmap in biocatalytic nylon recycling
www.nature.com/articles/s41...
Nature Chemical Biology
Glucose deprivation promotes OXCT1 phosphorylation and nuclear translocation, which leads to repressed transcription of MHC-I and chemokine genes and reduced immunotherapy responsiveness
www.nature.com/articles/s41...
Oxygen-dependent and photoreactive APEX2-based proximity labeling using a chemically evolved biotin probe for applications in living cells and in vivo
www.nature.com/articles/s41...
A new paper reports identification of a binder of IRF4 and development of a selective degrader that exhibits strong cytotoxicity against multiple myeloma cell lines
www.nature.com/articles/s41...
A new Review on using large-scale glycomics to understand glycan function #glycotime
www.nature.com/articles/s41...
Cystine C-S bond cleavage fuels cysteine production under disulfide reductase deficiency
www.nature.com/articles/s41...
Our June issue is live with a focus on RNA chemical biology
www.nature.com/nchembio/vol...
The cover image depicts the ribozyme SAMURI, which catalyzes transfer of alkyl groups from SAM to a specific adenosine in target RNA, represented as igniting a chemical spark
Nature Chemical Biology
Nature Chemical Biology
Nature Chemical Biology
Nature Chemical Biology
Nature Chemical Biology
Nature Chemical Biology
Nature Chemical Biology
Nature Chemical Biology
Metabolic reprogramming in cancer cells can contribute to responsiveness to immunotherapy. In this study, glucose deprivation in hepatocellular carcinoma cells was found to promote OXCT1 S113 phosphor...
www.nature.com
The H2O2 dependence of APEX2 and the toxicity of H2O2 hinder the use of APEX2-based proximity labeling in vivo. Now, APEX2 is rendered blue light activated with oxygen-dependent and low-H2O2-responsiv...
The enzymatic depolymerization of synthetic polyamides remains a major challenge. Here Bell et al. review the current biocatalytic nylon recycling landscape, highlighting the biochemical, structural a...
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Cells reduce the S–S bond in cystine to obtain cysteine. A robust alternative pathway, initiating with enzymatic cleavage of a cystine C–S bond followed by nonenzymatic reactions, is here shown to sup...
Identification of a binder of interferon regulatory factor 4 (IRF4) enabled development of a selective degrader, dIRF4-2, that exhibited strong cytotoxicity in multiple myeloma cell lines, offering an...
www.nature.com
Recent technological advances are enabling a growing number of large-scale glycomics studies. This Review discusses the challenges in high-throughput glycoanalytical methods with special attention to ...
Our June issue is live with a focus on RNA chemical biology
www.nature.com/nchembio/vol...
The cover image depicts the ribozyme SAMURI, which catalyzes transfer of alkyl groups from SAM to a specific adenosine in target RNA, represented as igniting a chemical spark
