My friends are out and about again! Spring has officially sprung in Connecticut! 🦎
A pressure relief valve for #lysosomes. @laylanassar.bsky.social and @shawnferguson.bsky.social @yaleschoolofmed.bsky.social discuss Kim et al.’s new study (doi.org/10.1083/jcb....): rupress.org/jcb/article-...
@laylanassar.bsky.social & @shawnferguson.bsky.social @yaleschoolofmed.bsky.social discuss Kim et al.’s study (doi.org/10.1083/jcb....) showing that TMEM63A protects #lysosomes from rupture by acting as a pressure relief valve when membrane tension rises. rupress.org/jcb/article/...
shawnferguson.bsky.social
Journal of Cell Biology
Loon visited this morning
Rainy night friend
New to me. Painted trillium. Colton, NY
It was a pleasure to work with @laylanassar.bsky.social to highlight this paper from @spencerfreeman.bsky.social and colleagues that shows how lysosomes can adapt in response to increased membrane tension
Journal of Cell Biology
How do lysosomes rapidly adapt to membrane tension to avoid bursting? In this article, @laylanassar.bsky.social and I highlight discoveries from Angela Kim, Spencer Freeman and colleagues who show a role for TMEM63A, a mechanosensitive cation channel in protecting lysosomes doi.org/10.1083/jcb....
Last “ice neurons” of the year? Near Tupper Lake, NY last week
Spotted salamander eggs in a vernal pool. Killingworth, CT
shawnferguson.bsky.social
shawnferguson.bsky.social
shawnferguson.bsky.social
Nassar and Ferguson discuss work from Kim et al. showing that TMEM63A protects lysosomes from rupture by acting as a pressure relief valve when membrane te
@laylanassar.bsky.social & @shawnferguson.bsky.social @yaleschoolofmed.bsky.social discuss Kim et al.’s study in @jcb.org (doi.org/10.1083/jcb....) showing that TMEM63A protects #lysosomes from rupture by acting as a pressure relief valve when membrane tension rises. rupress.org/jcb/article/...
