Cell Biologist and Neuroscientist at Yale University. Outdoor explorer.
shawnferguson.bsky.social
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How do lysosomes rapidly adapt to membrane tension to avoid bursting? In this article, @laylanassar.bsky.social and I highlight discoveries from Angela Kim, Spencer Freeman and colleagues who show a role for TMEM63A, a mechanosensitive cation channel in protecting lysosomes doi.org/10.1083/jcb....
Nassar and Ferguson discuss work from Kim et al. showing that TMEM63A protects lysosomes from rupture by acting as a pressure relief valve when membrane te
@laylanassar.bsky.social & @shawnferguson.bsky.social @yaleschoolofmed.bsky.social discuss Kim et al.’s study (doi.org/10.1083/jcb....) showing that TMEM63A protects #lysosomes from rupture by acting as a pressure relief valve when membrane tension rises. rupress.org/jcb/article/...
New to me. Painted trillium. Colton, NY
shawnferguson.bsky.social
A pressure relief valve for #lysosomes. @laylanassar.bsky.social and @shawnferguson.bsky.social @yaleschoolofmed.bsky.social discuss Kim et al.’s new study (doi.org/10.1083/jcb....): rupress.org/jcb/article-...
shawnferguson.bsky.social
Journal of Cell Biology
Loon visited this morning
Rainy night friend
Journal of Cell Biology
Spotted salamander eggs in a vernal pool. Killingworth, CT
My friends are out and about again! Spring has officially sprung in Connecticut! 🦎
Last “ice neurons” of the year? Near Tupper Lake, NY last week
It was a pleasure to work with @laylanassar.bsky.social to highlight this paper from @spencerfreeman.bsky.social and colleagues that shows how lysosomes can adapt in response to increased membrane tension
shawnferguson.bsky.social
shawnferguson.bsky.social
shawnferguson.bsky.social
shawnferguson.bsky.social
shawnferguson.bsky.social
shawnferguson.bsky.social
@laylanassar.bsky.social & @shawnferguson.bsky.social @yaleschoolofmed.bsky.social discuss Kim et al.’s study in @jcb.org (doi.org/10.1083/jcb....) showing that TMEM63A protects #lysosomes from rupture by acting as a pressure relief valve when membrane tension rises. rupress.org/jcb/article/...
