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It was a pleasure to work with @laylanassar.bsky.social to highlight this paper from @spencerfreeman.bsky.social and colleagues that shows how lysosomes can adapt in response to increased membrane tension
1mo
A pressure relief valve for #lysosomes. @laylanassar.bsky.social and @shawnferguson.bsky.social @yaleschoolofmed.bsky.social discuss Kim et al.’s new study (doi.org/10.1083/jcb....): rupress.org/jcb/article-...
1mo
Loon visited this morning
25d
shawnferguson.bsky.social
1mo
@laylanassar.bsky.social & @shawnferguson.bsky.social @yaleschoolofmed.bsky.social discuss Kim et al.’s study in @jcb.org (doi.org/10.1083/jcb....) showing that TMEM63A protects #lysosomes from rupture by acting as a pressure relief valve when membrane tension rises. rupress.org/jcb/article/...
@laylanassar.bsky.social & @shawnferguson.bsky.social @yaleschoolofmed.bsky.social discuss Kim et al.’s study (doi.org/10.1083/jcb....) showing that TMEM63A protects #lysosomes from rupture by acting as a pressure relief valve when membrane tension rises. rupress.org/jcb/article/...
Journal of Cell Biology
shawnferguson.bsky.social
1mo
Rockefeller University Press
New to me. Painted trillium. Colton, NY
Journal of Cell Biology
Last “ice neurons” of the year? Near Tupper Lake, NY last week
My friends are out and about again! Spring has officially sprung in Connecticut! 🦎
Rainy night friend
27d
Spotted salamander eggs in a vernal pool. Killingworth, CT
1mo
1mo
1mo
1mo
How do lysosomes rapidly adapt to membrane tension to avoid bursting? In this article, @laylanassar.bsky.social and I highlight discoveries from Angela Kim, Spencer Freeman and colleagues who show a role for TMEM63A, a mechanosensitive cation channel in protecting lysosomes doi.org/10.1083/jcb....
shawnferguson.bsky.social
1mo
shawnferguson.bsky.social
shawnferguson.bsky.social
shawnferguson.bsky.social
shawnferguson.bsky.social
Nassar and Ferguson discuss work from Kim et al. showing that TMEM63A protects lysosomes from rupture by acting as a pressure relief valve when membrane te
doi.org
A pressure relief valve for lysosomes
shawnferguson.bsky.social