How do lysosomes rapidly adapt to membrane tension to avoid bursting? In this article, @laylanassar.bsky.social and I highlight discoveries from Angela Kim, Spencer Freeman and colleagues who show a role for TMEM63A, a mechanosensitive cation channel in protecting lysosomes doi.org/10.1083/jcb....
Nassar and Ferguson discuss work from Kim et al. showing that TMEM63A protects lysosomes from rupture by acting as a pressure relief valve when membrane te
