Watching reaction-diffusion signaling couple to protein condensations feels like opening a new world of exotic subcellular spatial patterning 🌌 huge thanks to the evolving idea started from @edenchang.bsky.social and @cellraiser.bsky.social that make this journey possible and incredibly fun!
Sub-cellular architectures arise through integrating signaling and structure. @edenchang.bsky.social and @zjmaggiexu.bsky.social show how coupling reaction-diffusion signaling to protein condensation provides a tunable, regulatable landscape for sub-cellular structure www.biorxiv.org/content/10.6...
Sub-cellular architectures arise through integrating signaling and structure. @edenchang.bsky.social and @zjmaggiexu.bsky.social show how coupling reaction-diffusion signaling to protein condensation provides a tunable, regulatable landscape for sub-cellular structure www.biorxiv.org/content/10.6...
The array of organs in the animal body differ dramatically in their architecture, but cell-cell adhesion mediated by cadherins is a common principle. Our lab usually focuses on epithelia but cadherins are also active in migrating mesenchymal cells like these migrating testis myoblasts 1/n 🧪
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Scott Coyle
Big paper from @hejnol.bsky.social lab. Title says it all. Congrats, Stanislav Kremnyov and the team.
www.nature.com/articles/s41...
Make sure to check our latest collaboration with @kaitezhang.bsky.social and @vram142.bsky.social. An effort to move towards simulating non-ideal, "in vivo" chromatin, and learning lots about chromatin organisation while doing it!
@juliamaristany.bsky.social @rcollepardo.bsky.social
Mark Peifer (He, him)
Now online @pnas.org: We developed a simple, scalable, and accessible platform for deep profiling of phosphoeraser specificity using human phosphoproteome-derived peptide libraries (PhosPropels!) 🧪👩🔬https://www.pnas.org/doi/10.1073/pnas.2523183123
Join us for Zhejing (Maggie) Xu's Ph.D. thesis defense on May 11! As a member of the @cellraiser.bsky.social Lab, Xu studied how predatory protozoa adapt cell morphology to optimize feeding efficiency in response to environmental demands. Learn more: ipib.wisc.edu/2026/04/17/i...
Experiments using the comb jelly Mnemiopsis leidyi and the sea anemone Nematostella vectensis reveal that the emergence of a core signalling pathway may have been a key innovation enabling the transit...
Excited to share our new bioRxiv preprint!
We introduce RIPPLE, a synthetic platform that couples reaction–diffusion signaling with protein condensation to generate tunable intracellular architectures.
Grateful to @zjmaggiexu.bsky.social and @cellraiser.bsky.social. It’s been a rewarding journey.
Jan Huertas
Amy Weeks
UW–Madison Department of Biochemistry
Sub-cellular architectures arise through integrating signaling and structure. @edenchang.bsky.social and @zjmaggiexu.bsky.social show how coupling reaction-diffusion signaling to protein condensation provides a tunable, regulatable landscape for sub-cellular structure www.biorxiv.org/content/10.6...
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Scott Coyle
JIT 4 summer, the latest preprint from our lab, brilliantly led by @kaitezhang.bsky.social w/ support from Collepardo lab (@juliamaristany.bsky.social / @janhuemar.bsky.social). www.biorxiv.org/content/10.6... describes a new single-molecule epigenomic method, & discoveries it enables ... (1/n)
JIT 4 summer, the latest preprint from our lab, brilliantly led by @kaitezhang.bsky.social w/ support from Collepardo lab (@juliamaristany.bsky.social / @janhuemar.bsky.social). www.biorxiv.org/content/10.6... describes a new single-molecule epigenomic method, & discoveries it enables ... (1/n)
Nucleosome spacing influences higher-order chromatin fiber organization in vitro but how this relates to cellular chromosome structure remains contentious. To address this, we developed Ligation Analy...
Nucleosome spacing influences higher-order chromatin fiber organization in vitro but how this relates to cellular chromosome structure remains contentious. To address this, we developed Ligation Analy...
