Watching reaction-diffusion signaling couple to protein condensations feels like opening a new world of exotic subcellular spatial patterning 🌌 huge thanks to the evolving idea started from @edenchang.bsky.social and @cellraiser.bsky.social that make this journey possible and incredibly fun!
The array of organs in the animal body differ dramatically in their architecture, but cell-cell adhesion mediated by cadherins is a common principle. Our lab usually focuses on epithelia but cadherins are also active in migrating mesenchymal cells like these migrating testis myoblasts 1/n 🧪
JIT 4 summer, the latest preprint from our lab, brilliantly led by @kaitezhang.bsky.social w/ support from Collepardo lab (@juliamaristany.bsky.social / @janhuemar.bsky.social). www.biorxiv.org/content/10.6... describes a new single-molecule epigenomic method, & discoveries it enables ... (1/n)
Now online @pnas.org: We developed a simple, scalable, and accessible platform for deep profiling of phosphoeraser specificity using human phosphoproteome-derived peptide libraries (PhosPropels!) 🧪👩🔬https://www.pnas.org/doi/10.1073/pnas.2523183123
Sub-cellular architectures arise through integrating signaling and structure. @edenchang.bsky.social and @zjmaggiexu.bsky.social show how coupling reaction-diffusion signaling to protein condensation provides a tunable, regulatable landscape for sub-cellular structure www.biorxiv.org/content/10.6...
www.youtube.com/watch?v=Gtd1...
Excited to share our new bioRxiv preprint!
We introduce RIPPLE, a synthetic platform that couples reaction–diffusion signaling with protein condensation to generate tunable intracellular architectures.
Grateful to @zjmaggiexu.bsky.social and @cellraiser.bsky.social. It’s been a rewarding journey.
Big paper from @hejnol.bsky.social lab. Title says it all. Congrats, Stanislav Kremnyov and the team.
www.nature.com/articles/s41...
Make sure to check our latest collaboration with @kaitezhang.bsky.social and @vram142.bsky.social. An effort to move towards simulating non-ideal, "in vivo" chromatin, and learning lots about chromatin organisation while doing it!
@juliamaristany.bsky.social @rcollepardo.bsky.social
Join us for Zhejing (Maggie) Xu's Ph.D. thesis defense on May 11! As a member of the @cellraiser.bsky.social Lab, Xu studied how predatory protozoa adapt cell morphology to optimize feeding efficiency in response to environmental demands. Learn more: ipib.wisc.edu/2026/04/17/i...
Video
Video
Nucleosome spacing influences higher-order chromatin fiber organization in vitro but how this relates to cellular chromosome structure remains contentious. To address this, we developed Ligation Analy...
www.biorxiv.org
Protein phosphorylation is dynamically regulated by the opposing activities of phosphowriter
enzymes (kinases) and phosphoeraser enzymes (phosphata...
Experiments using the comb jelly Mnemiopsis leidyi and the sea anemone Nematostella vectensis reveal that the emergence of a core signalling pathway may have been a key innovation enabling the transit...
Sub-cellular architectures arise through integrating signaling and structure. @edenchang.bsky.social and @zjmaggiexu.bsky.social show how coupling reaction-diffusion signaling to protein condensation provides a tunable, regulatable landscape for sub-cellular structure www.biorxiv.org/content/10.6...
Zhejing (Maggie) Xu
Mark Peifer (He, him)
Jan Huertas
Vijay Ramani
Amy Weeks
Scott Coyle
Sub-cellular architectures arise through integrating signaling and structure. @edenchang.bsky.social and @zjmaggiexu.bsky.social show how coupling reaction-diffusion signaling to protein condensation provides a tunable, regulatable landscape for sub-cellular structure www.biorxiv.org/content/10.6...
JIT 4 summer, the latest preprint from our lab, brilliantly led by @kaitezhang.bsky.social w/ support from Collepardo lab (@juliamaristany.bsky.social / @janhuemar.bsky.social). www.biorxiv.org/content/10.6... describes a new single-molecule epigenomic method, & discoveries it enables ... (1/n)
Video
UW–Madison Department of Biochemistry
Video
Scott Coyle
Nucleosome spacing influences higher-order chromatin fiber organization in vitro but how this relates to cellular chromosome structure remains contentious. To address this, we developed Ligation Analy...
