Very excited to be sharing our new paper, just out in Nature Cell Biology!
The big question we investigate: How do migrating cells put their front 🔴 and back 🔵 in the right place?
Video
In the W-S lab's first preprint, we describe how genomic language models know something about RNA thermodynamics. Though we think this is cool, things get tricky!
A growing practice for interpreting LMs is to perturb input tokens, often called "Categorical Jacobian": 👇
How do cells tune PRC2 allostery? We find EZH2 Ser21-phos restrains PRC2 adoption of the compact active state. Loss of this restraint promotes H3K27me3, redistributes cPRC1, and impairs differentiation. New bioRxiv with @kasinath-lab.bsky.social & @garcialabms.bsky.social! tinyurl.com/4369kmh2
And now it's out! Happy that PNAS selected for the cover this SEM image snapped by @samjlord.bsky.social, one of the most evocative visualizations of Euplotes that I have ever encountered.
www.pnas.org/doi/10.1073/...
Stay tuned for what is shaping up to be some fascinating follow-up in the lab...
Now online @pnas.org: We developed a simple, scalable, and accessible platform for deep profiling of phosphoeraser specificity using human phosphoproteome-derived peptide libraries (PhosPropels!) 🧪👩🔬https://www.pnas.org/doi/10.1073/pnas.2523183123
1/13 So excited to share our new preprint!! How do organelles pack together in a crowded cytoplasm? we know organelles interact via contact sites, but how does competition for space contribute to organelle morphology and interactions?
@wallaceucsf.bsky.social
www.biorxiv.org/content/10.6...
Congratulations to Gautam Dey (EMBL) and Omaya Dudin (University of Geneva) for being awarded the EMBO Gold Medal 2026 in recognition of their outstanding contributions to the #LifeSciences in Europe! 🧪 https://www.embo.org/press-releases/embo-gold-medal-2026-awarded-to-gautam-dey-and-omaya-dudin/
Protein phosphorylation is dynamically regulated by the opposing activities of phosphowriter
enzymes (kinases) and phosphoeraser enzymes (phosphata...
www.pnas.org
First lab sampling expedition. Turns out we don't even need to leave campus to find delightful protists.
Congratulations to Sourav Agrawal, who was awarded a Louis and Elsa Thomsen Wisconsin Distinguished Graduate Fellowship from @uwmadisoncals.bsky.social! His research in the @cijilim.bsky.social Lab focuses on telomeres. Learn more: biochem.wisc.edu/2026/04/28/s...
The Lewis Lab
Hannah Wayment-Steele
Mary Mirvis
EMBO
Agrawal is one of two CALS students awarded the 2026 Louis and Elsa Thomsen Wisconsin Distinguished Graduate Fellowship.
What could be more exciting than watching Euplotes scurry around under the microscope? How about adding some raptorial predation by supergiant cannibal cells?
www.biorxiv.org/content/10.1...
Video by Vittorio Boscaro.
1/n
Manuel Thery
UW–Madison Department of Biochemistry
Video
Cellular structure self-organizes through an interplay between internal mechanisms and external cues. The single-celled suctorian P. collini builds a trap structure to capture large prey using microtubule feeding tentacles, creating feedback between cell morphology and prey availability.
