Excited that our paper on enzymatic bromination of peptides is now online at ACS Chemical Biology! Led by Haley Bridge, we showed that the flavin-dependent halogenase RebH and its variants can be used for late-stage chemoenzymatic diversification of bioactive peptides: pubs.acs.org/doi/10.1021/...
🚨 excited to share our latest preprint on bioRxiv, led by the soon-to-be Dr. Guy Kunzmann!
We tackle a striking case of conditional dependence on UFMylation, a UBL modification pathway whose contributions to cell fitness have been a bit of a "black box." 🧵
Flavin-dependent halogenases (FDHs) provide a biocatalytic approach for the site-selective halogenation of aromatic compounds, but their use in late-stage functionalization of peptides has remained li...pubs.acs.org
Thanks to the Ono Pharma Foundation and The University of Chicago for supporting this amazing symposium! And congratulations to the Weeks lab's own Sopo Jalalishvili for winning a poster prize for her work on phospholyases! 👩🔬🧪@uwbiochem.bsky.social
Huge congratulations to my student Rohith Rajasekaran @born2raisecell.bsky.social (now a postdoc in Kole Roybal's lab at UCSF) on being selected for a Weintraub award! Super proud of you and all the work you've done!
Congratulations to my student Dennis Bolshakov and his coauthors @weix.us, Tommy, and @born2raisecell.bsky.social on making the cover of ACS Synthetic Biology! A great paper and an awesome cover 🥳 pubs.acs.org/doi/10.1021/...
Super excited that our SEE-CITE photoaffinity labeling method is now out in @natchem.nature.com rdcu.be/ffBSC. Here we introduce a custom silyl ether cleavable linker between a diazirine photocrosslinker handle and molecules of interest to streamline site-of-labeling analysis for PAL chemoproteomics
Jason Cantor
Dynamic UFMylation governs cellular fitness by coordinating multi-organelle proteostasis https://www.biorxiv.org/content/10.64898/2026.03.27.714830v1
