👍👍👍 Landmark work in the embryo model field. MZG: establishing a close cross-talk between emb and exe in a 3D ECM scaffold is necessary and sufficient for the self-assembly.
Very happy to be part of this wonderful team! 😀😀😀
Very nice work👍
Moving forward! induced ETX. MGZ: iETX embryos establish a robust anterior signaling center that migrates unilaterally to break embryo symmetry.
Step-wise induction of totipotent-like cell-based embryo model. J Xu: It recapitulates key developmental milestones, including zygotic genome activation in 2-cell embryos, the formation of blastocysts and the subsequent development into post-implantation egg cylinders.
It takes three to initiate gastrulation. MGZ: Three stem cell types self-assemble in vitro into gastrulating embryo-like structures undertaking spatiotemporal events of the gastrulating mammalian embryo.
👍👍👍 induced assemble+ Ex Utero culture lead to advanced embryogenesis. JH: Post-gastrulation stages of development
with organ progenitors and complex extra-embryonic compartments are achieved ex utero entirely from assembled naive mouse embryonic stem cells.
EiTiX undergoes neurulation and heart development. MGZ: This unified model recapitulates developmental events from embryonic day 5.5 to 8.5 (gastrulation; formation of AP axis, brain, and a beating heart structure; and the development of extraembryonic tissues, including yolk sac and chorion).
Meet our Preprint Editors
We are pleased to welcome Xianfa Yang to our first group of Preprint Editors to our editorial team, responsible for handling our 'In preprints' articles.
journals.biologists.com/dev/pages/pr...
Totipotent like TBLCs mimic early embryogenesis. P Du: single TBLCs underwent expansion, compaction, and polarization to efficiently generate blastocyst-like structures and even post-implantation egg-cylinder-like structures.
