Step-wise induction of totipotent-like cell-based embryo model. J Xu: It recapitulates key developmental milestones, including zygotic genome activation in 2-cell embryos, the formation of blastocysts and the subsequent development into post-implantation egg cylinders.
The authors identify a chemical cocktail to generate totipotent-like cells, which they then use to build an embryo model. This model captures a developmental spectrum from early embryogenesis to post-...
Totipotent like TBLCs mimic early embryogenesis. P Du: single TBLCs underwent expansion, compaction, and polarization to efficiently generate blastocyst-like structures and even post-implantation egg-cylinder-like structures.
Yang XF
Du and colleagues model early embryonic development using mouse totipotent blastomere-like
cells (mTBLCs). This system captures key events such as cell fate determination, compaction,
and polarization...
Very nice work!👍 WQ Liu: Integration of BPSCs with PrE induction system enables high-efficiency generation of E8.5-stage embryo models.
www.nature.com/articles/s41...
Yang XF
Cell Research - Modeling post-gastrula development via bidirectional pluripotent stem cells
