Step-wise induction of totipotent-like cell-based embryo model. J Xu: It recapitulates key developmental milestones, including zygotic genome activation in 2-cell embryos, the formation of blastocysts and the subsequent development into post-implantation egg cylinders.
👍👍👍 Landmark work in the embryo model field. MZG: establishing a close cross-talk between emb and exe in a 3D ECM scaffold is necessary and sufficient for the self-assembly.
Very happy to be part of this wonderful team! 😀😀😀
Totipotent like TBLCs mimic early embryogenesis. P Du: single TBLCs underwent expansion, compaction, and polarization to efficiently generate blastocyst-like structures and even post-implantation egg-cylinder-like structures.
Very nice work! Inhibition of Hippo signaling, activation of Wnt signaling and TGFbeta signaling give rise to MTSC. J Zhang: Mouse trophectoderm stem cells generated with morula signalling inducers capture an
early trophectoderm state
👍👍👍 induced assemble+ Ex Utero culture lead to advanced embryogenesis. JH: Post-gastrulation stages of development
with organ progenitors and complex extra-embryonic compartments are achieved ex utero entirely from assembled naive mouse embryonic stem cells.
Very nice work!👍 WQ Liu: Integration of BPSCs with PrE induction system enables high-efficiency generation of E8.5-stage embryo models.
www.nature.com/articles/s41...
It takes three to initiate gastrulation. MGZ: Three stem cell types self-assemble in vitro into gastrulating embryo-like structures undertaking spatiotemporal events of the gastrulating mammalian embryo.
Moving forward! induced ETX. MGZ: iETX embryos establish a robust anterior signaling center that migrates unilaterally to break embryo symmetry.
Meet our Preprint Editors
We are pleased to welcome Xianfa Yang to our first group of Preprint Editors to our editorial team, responsible for handling our 'In preprints' articles.
journals.biologists.com/dev/pages/pr...
Yang XF
Yang XF
Yang XF
Yang XF
Yang XF
Yang XF
Yang XF
Yang XF
Yang XF
Development
Meet our Preprint Editors
We are pleased to welcome Xianfa Yang to our first group of Preprint Editors to our editorial team, responsible for handling our 'In preprints' articles.
journals.biologists.com/dev/pages/pr...
Development
Embryonic and trophoblast stem cells self-assemble to generate a structure resembling a natural mouse embryo.
Du and colleagues model early embryonic development using mouse totipotent blastomere-like
cells (mTBLCs). This system captures key events such as cell fate determination, compaction,
and polarization...
Very nice work!👍 WQ Liu: Integration of BPSCs with PrE induction system enables high-efficiency generation of E8.5-stage embryo models.
www.nature.com/articles/s41...
Yang XF
In vitro cultured stem cells with distinct developmental capacities can contribute to embryonic or extraembryonic tissues after microinjection into pr…
Cell Research - Modeling post-gastrula development via bidirectional pluripotent stem cells
www.nature.com
The development of mouse embryos can be partially recapitulated by combining embryonic stem cells (ESCs), trophoblast stem cells (TS), and extra-embry…
The authors identify a chemical cocktail to generate totipotent-like cells, which they then use to build an embryo model. This model captures a developmental spectrum from early embryogenesis to post-...
www.nature.com
Sozen et al. devise an approach to combine embryonic stem cells, trophoblast stem cells and extra-embryonic endoderm stem cells into self-assembling embryo-like structures, which recapitulate key hall...
It takes three to initiate gastrulation. MGZ: Three stem cell types self-assemble in vitro into gastrulating embryo-like structures undertaking spatiotemporal events of the gastrulating mammalian embryo.
Gao, Li and colleagues derive trophectoderm stem cells from 32-cell mouse embryos. These cells represent an early trophectoderm state and are capable of developing into placenta cells, forming placent...
Totipotent like TBLCs mimic early embryogenesis. P Du: single TBLCs underwent expansion, compaction, and polarization to efficiently generate blastocyst-like structures and even post-implantation egg-cylinder-like structures.
👍👍👍 Landmark work in the embryo model field. MZG: establishing a close cross-talk between emb and exe in a 3D ECM scaffold is necessary and sufficient for the self-assembly.
Cell Research - Modeling post-gastrula development via bidirectional pluripotent stem cells
Sozen et al. devise an approach to combine embryonic stem cells, trophoblast stem cells and extra-embryonic endoderm stem cells into self-assembling embryo-like structures, which recapitulate key hall...
Du and colleagues model early embryonic development using mouse totipotent blastomere-like
cells (mTBLCs). This system captures key events such as cell fate determination, compaction,
and polarization...
👍👍👍 Landmark work in the embryo model field. MZG: establishing a close cross-talk between emb and exe in a 3D ECM scaffold is necessary and sufficient for the self-assembly.
Very nice work!👍 WQ Liu: Integration of BPSCs with PrE induction system enables high-efficiency generation of E8.5-stage embryo models.
www.nature.com/articles/s41...
Embryonic and trophoblast stem cells self-assemble to generate a structure resembling a natural mouse embryo.
www.science.org
Cell Research - Modeling post-gastrula development via bidirectional pluripotent stem cellswww.nature.com
