Our H1 paper is out #ScienceAdvances:
www.science.org/doi/10.1126/...
@masaashimazoe.bsky.social et al. reveal that linker histone H1 acts as a liquid-like glue to organize chromatin in live cells. 🎉 Fantastic collab with @rcollepardo.bsky.social @janhuemar.bsky.social and others—huge thanks! 🙌 1/
Video
Kazuhiro Maeshima
I am not afraid to say it: this is the most fundamental advance in our understanding of chromatin structure since the zig-zag fiber model. Congratulations!
Great to be back at CSHL!!!
Tomorrow I’ll be giving a talk at the CSHL meeting “Genome Organization & Nuclear Function” #cshlnucleus
Can’t wait to share our work and discuss!
Single molecule imaging revealed that H1 behaves like a liquid inside chromatin! 🫧
It's amazing to witness how H1 behaves in living cells 🔬✨
(3/n)
Q. What is the benefit of a liquid-like “glue”?
A. Fluidity makes transcription, DNA replication, repair, and other reactions easier. In other words, H1 helps keep chromatin compact, yet still accessible!
Finally, I truly appreciate the contributions of all the authors!
(5/5)
Huge thanks to Rosana @rcollepardo.bsky.social , Jan @janhuemar.bsky.social , Charlie, and Stephen! 🙌
Their simulations revealed in stunning detail how H1 and nucleosomes interact.
I was amazed—so consistent with our experiments! 🔬💻
(4/n)
Check out our latest work in collaboration with @kazu-maeshima.bsky.social and @masaashimazoe.bsky.social
We show that H1 is a dynamic, multivalent “liquid-like” glue of chromatin in cells: it bridges multiple nucleosomes & exchanges partners frequently to enable both compaction and flexibility
H1 is the most abundant chromatin protein, condensing chromatin—but how? 🤔
The textbook model suggests H1 stabilizes 30-nm fiber, but recent studies dispute this. So, what's the true mechanism?
We think: H1 acts as a liquid-like "glue"! (2/n)
A new model provides insight into chromatin organization and dynamics in living cells.
Learn more in this week’s issue of #ScienceAdvances: https://scim.ag/4sYMeyS
My first, first author paper is now on #ScienceAdvances !
Linker histone H1 is a liquid-like "glue" condensing chromatin, which revises textbooks! 📖✨
science.org/doi/10.1126/sc…
Huge thanks to @kazu-maeshima.bsky.social , for supervision.
Amazing collab with @rcollepardo.bsky.social ’s group! 1/
Masa A. Shimazoe
Masa A. Shimazoe
Masa A. Shimazoe
Masa A. Shimazoe
Masa A. Shimazoe
science.org
Masa A. Shimazoe
Rosana Collepardo
Our linker histone H1 paper is featured on the cover of the April 10 issue of #ScienceAdvances.
www.science.org/doi/10.1126/...
A molecular dynamics simulation of nucleosomes and linker histone H1, with single-H1 trajectories (background). 🎉 Full cover caption: www.science.org/toc/sciadv/1...
