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Ph. D. Student in Maeshima lab in NIG @kazu-maeshima.bsky.social Biophysics, Chromatin / Kyoto Uni. → NIG https://sites.google.com/view/masa-a-shimazoe/home

Masa A. Shimazoe

Great to be back at CSHL!!! Tomorrow I’ll be giving a talk at the CSHL meeting “Genome Organization & Nuclear Function” #cshlnucleus Can’t wait to share our work and discuss!

Check out our latest work in collaboration with @kazu-maeshima.bsky.social and @masaashimazoe.bsky.social We show that H1 is a dynamic, multivalent “liquid-like” glue of chromatin in cells: it bridges multiple nucleosomes & exchanges partners frequently to enable both compaction and flexibility

I am not afraid to say it: this is the most fundamental advance in our understanding of chromatin structure since the zig-zag fiber model. Congratulations!

A new model provides insight into chromatin organization and dynamics in living cells. Learn more in this week’s issue of #ScienceAdvances: https://scim.ag/4sYMeyS

Our H1 paper is out #ScienceAdvances: www.science.org/doi/10.1126/... @masaashimazoe.bsky.social et al. reveal that linker histone H1 acts as a liquid-like glue to organize chromatin in live cells. 🎉 Fantastic collab with @rcollepardo.bsky.social @janhuemar.bsky.social and others—huge thanks! 🙌 1/

Q. What is the benefit of a liquid-like “glue”? A. Fluidity makes transcription, DNA replication, repair, and other reactions easier. In other words, H1 helps keep chromatin compact, yet still accessible! Finally, I truly appreciate the contributions of all the authors! (5/5)

Huge thanks to Rosana @rcollepardo.bsky.social , Jan @janhuemar.bsky.social , Charlie, and Stephen! 🙌 Their simulations revealed in stunning detail how H1 and nucleosomes interact. I was amazed—so consistent with our experiments! 🔬💻 (4/n)

Single molecule imaging revealed that H1 behaves like a liquid inside chromatin! 🫧 It's amazing to witness how H1 behaves in living cells 🔬✨ (3/n)