Single molecule imaging revealed that H1 behaves like a liquid inside chromatin! đź«§
It's amazing to witness how H1 behaves in living cells 🔬✨
(3/n)
Video
Q. What is the benefit of a liquid-like “glue”?
A. Fluidity makes transcription, DNA replication, repair, and other reactions easier. In other words, H1 helps keep chromatin compact, yet still accessible!
Finally, I truly appreciate the contributions of all the authors!
(5/5)
Great to be back at CSHL!!!
Tomorrow I’ll be giving a talk at the CSHL meeting “Genome Organization & Nuclear Function” #cshlnucleus
Can’t wait to share our work and discuss!
Thank you so much! That means a lot to me. I’m really happy to see the paper finally out.
H1 is the most abundant chromatin protein, condensing chromatin—but how? 🤔
The textbook model suggests H1 stabilizes 30-nm fiber, but recent studies dispute this. So, what's the true mechanism?
We think: H1 acts as a liquid-like "glue"! (2/n)