A question for the experts: Can you recognize nucleosomes and linker DNA in this data?
Find an updated version of our manuscript in
www.biorxiv.org/content/10.1...
I am not afraid to say it: this is the most fundamental advance in our understanding of chromatin structure since the zig-zag fiber model. Congratulations!
We are in EMBO J. See DNA and non-octameric nucleosome-like particles in situ
link.springer.com/article/10.1...
Video
Generate synthetic cryo-ET data and train your model for particle picking in real data.
Impressive work by Mohamad Harastani:
www.nature.com/articles/s41...
Chromatin organization, through the assembly of DNA with histones and the folding of nucleosome chains, regulates DNA accessibility for transcription, DNA replication and repair. Although models deriv...
Using single-H1 imaging and computational modeling, we show that most H1 behaves like a liquid inside chromatin domains rather than binding stably to nucleosomes as in the textbook model:
www.science.org/doi/10.1126/...
Congrats
@masaashimazoe.bsky.social & all contributors! 🎉 2/
Particle picking is a key bottleneck in bridging structural and cell biology with cryo-electron tomography. Here, authors develop Template Learning, using domain-randomized simulations to train deep l...
Our linker histone H1 paper is featured on the cover of the April 10 issue of #ScienceAdvances.
www.science.org/doi/10.1126/...
A molecular dynamics simulation of nucleosomes and linker histone H1, with single-H1 trajectories (background). 🎉 Full cover caption: www.science.org/toc/sciadv/1...
Kazuhiro Maeshima
Kazuhiro Maeshima
Our H1 paper is out #ScienceAdvances:
www.science.org/doi/10.1126/...
@masaashimazoe.bsky.social et al. reveal that linker histone H1 acts as a liquid-like glue to organize chromatin in live cells. 🎉 Fantastic collab with @rcollepardo.bsky.social @janhuemar.bsky.social and others—huge thanks! 🙌 1/
