Microglial cGAS-STING-TBK1 activation in paraventricular thalamus mediates sleep and emotional disturbances in lupus mice www.sciencedirect.com/science/arti...
Single cell isoform profiling by snISOrseq2 reveals broad splicing dysregulation across different cell types in Progranulin-deficient human FTD! Congrats to @hagentilgner.bsky.social & @liganlab.bsky.social labs! Happy to have played a tiny role in this important study.
www.cell.com/cell-reports...
SPiNES was such a great experience. Highly recommend!
Great opportunity for neuroscience postdocs!
I am thrilled to announce that I will be starting my lab at
@washumedicine.bsky.social, Department of Pathology & Immunology as an Assistant Professor this month. The lab will study the role of innate immunity in neurodegeneration and brain aging. We'll be hiring at all levels. Details soon!
Huge thank you to my mentors @liganlab.bsky.social, @shuibingchen.bsky.social, @studerl.bsky.social and Shelley Berger for all the mentoring and support throughout my journey. Big shoutout to all present and past members of @liganlab.bsky.social for all their support along the way.
New article @natneuro.nature.com by @yaleneuro.bsky.social Suzhou Yang & @kavliatyale.bsky.social Postdoc Fellow @zhenlei.bsky.social, highlighting studies by @frattalab.bsky.social Gitler & La Spada labs on the role of TDP-43 on mRNA 3' end in ALS @yalerna.bsky.social www.nature.com/articles/s41...
Proud to announce our collaboration with @blurtonjoneslab.bsky.social & the Paz lab showing that transplanted human iPSC-derived microglia in a PGRN KO mouse model restores progranulin in microglia and rescues pathology, circuitry, and behavior. Preprint out now: www.biorxiv.org/cgi/content/...
🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...
Cell membrane stress upon viral infection induces expression and stabilization of host SMPDL3B, which, in turn, degrades cGAMP to suppress cGAS-STING signaling and promote viral replication @cp-immunity.bsky.social
www.cell.com/immunity/ful...
