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Our work investigating mRNA 3' UTRs that trigger target-directed miRNA degradation is now published! genesdev.cshlp.org/content/earl...
2mo
genesdev.cshlp.org
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
mRNA 3′ UTRs direct microRNA degradation to participate in imprinted gene networks and regulate growth
David Bartel's Lab
Check out the latest work from our lab, led by Daniel Lin and Lara Elcavage: www.biorxiv.org/content/10.1... (1/3)
7mo
www.biorxiv.org
MicroRNAs direct downregulation of target mRNAs. Sometimes, however, this regulatory paradigm inverts, and a target RNA triggers the degradation of a microRNA. This target-directed microRNA degradatio...
David Bartel's Lab
mRNA 3′ UTRs direct microRNA degradation to participate in imprinted gene networks and regulate growth
Check out the phenomenal PhD work by Katie Copley, a current postdoc in our lab @yaleneuro.bsky.social @yalerna.bsky.social. www.science.org/doi/10.1126/...
1mo
We bid farewell to @yaleneuro.bsky.social graduate Suzhou Yang, who discovered C9orf72 RNA cryptic splicing in ALS-FTD and will soon move to UCLA to start postdoc training with William Yang working on Huntington's disease. Can't wait to hear about your future successes! @yalerna.bsky.social
Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration
A full house of audience @yalerna.bsky.social learning from Dr. Xiang-Dong Fu from Westlake University about his latest work on transcriptional regulation in aging. He spoke separately with our trainees about his 40-year scientific career in the US and China. Thank you for visiting us!
1mo
Aberrant aggregation of the prion-like RNA binding protein TDP-43 drives several fatal neurodegenerative proteinopathies, including amyotrophic lateral sclerosis (ALS). In this work, we define how sho...
www.science.org
Congratulations to our @yaleneuro.bsky.social INP student Ata Isiktas for being selected as one of the ✨Rising Stars in Neuroscience✨ and to give a research talk @uuneurobiology.bsky.social @yalerna.bsky.social
1mo
26d
16d
It’s time for the final RNA Club of the academic year Tuesday, June 9 9:00 AM Hope 103, Yale School of Medicine Featuring great talks by the Lu & Gerstein Lab and the Simon Lab. Details in the flyer
Check out this Q&A by @alstdi.bsky.social highlighting Dr. Katie Copley, a Corsalex Postdoc Fellow in our lab @yaleneuro.bsky.social @yalerna.bsky.social ! The Corsalex Postdoctoral Fellowship program is now open for application: www.corsalex.com/corsalex-fel...
Thomas A. Steitz Lecture Series by @yalembb.bsky.social Dr. Rachel Green, “ZAK activation on the colliding ribosome”, hosted by Dr. Yong Xiong Monday, April 20 | 4:00 PM 📍O.C. Marsh Lecture Hall, Yale Science Building Open to Yale and affiliated institutions. Details in the flyer below
7d
1mo
Junjie Guo
Junjie Guo
Junjie Guo
Junjie Guo
Junjie Guo
Yale Center for RNA Science and Medicine
Yale Center for RNA Science and Medicine
"I always wanted to be a scientist." Pietro De Camilli’s journey from curious observation of nature as a child to understanding the molecular machinery of the brain has consistently been driven by an unwavering commitment to understanding life. @pdc-lab.bsky.social
26d
Pietro De Camilli always wanted to be a scientist. He has spent his career bridging cell biology and neuroscience.
medicine.yale.edu
Tending The Frontier: Pietro De Camilli and the Cell Biology of Neurons
🆕 review with @jpunfried.bsky.social out in Nature SMB. Direct roles of lncRNAs in transcriptional activation. What do we understand about how lncRNAs lure Pol2 and set the stage for RNA production, and what do we still miss? www.nature.com/articles/s41...
1mo
This Review discusses how long noncoding RNAs (lncRNAs) control transcription activation by RNA polymerase II, including how they are produced at active enhancers or chromatin-domain boundaries and ac...
www.nature.com
Direct roles of long non-coding RNAs in transcription activation - Nature Structural & Molecular Biology
Yale Neuroscience
Igor Ulitsky