Cell membrane stress upon viral infection induces expression and stabilization of host SMPDL3B, which, in turn, degrades cGAMP to suppress cGAS-STING signaling and promote viral replication @cp-immunity.bsky.social
www.cell.com/immunity/ful...
Waggoner Lab
SPiNES was such a great experience. Highly recommend!
Proud to announce our collaboration with @blurtonjoneslab.bsky.social & the Paz lab showing that transplanted human iPSC-derived microglia in a PGRN KO mouse model restores progranulin in microglia and rescues pathology, circuitry, and behavior. Preprint out now: www.biorxiv.org/cgi/content/...
Great opportunity for neuroscience postdocs!
Huge thank you to my mentors @liganlab.bsky.social, @shuibingchen.bsky.social, @studerl.bsky.social and Shelley Berger for all the mentoring and support throughout my journey. Big shoutout to all present and past members of @liganlab.bsky.social for all their support along the way.
Single cell isoform profiling by snISOrseq2 reveals broad splicing dysregulation across different cell types in Progranulin-deficient human FTD! Congrats to @hagentilgner.bsky.social & @liganlab.bsky.social labs! Happy to have played a tiny role in this important study.
www.cell.com/cell-reports...
New article @natneuro.nature.com by @yaleneuro.bsky.social Suzhou Yang & @kavliatyale.bsky.social Postdoc Fellow @zhenlei.bsky.social, highlighting studies by @frattalab.bsky.social Gitler & La Spada labs on the role of TDP-43 on mRNA 3' end in ALS @yalerna.bsky.social www.nature.com/articles/s41...
