A very well-written and thoughtful News & Views by Florence Besse and Andres Ramos contextualises the value of the study and sets the stage for what maybe comes next, www.nature.com/articles/s41...
So how do mRNAs get localised at specific areas of the cell if there are no unifying sequence or structural patterns? Work from the labs of @simonbullock11.bsky.social @carter-lab.bsky.social @natsmb.nature.com provides insightful answers to this longstanding question. www.nature.com/articles/s41...
back to back with related study from Jan-Michael Peters' group
PDS5 proteins control genome architecture by limiting the lifetime of cohesin-NIPBL complexes
www.cell.com/molecular-ce...
A group of great developers we know has made this entertaining and engaging game: store.steampowered.com/app/2437390/...
It's now on playtest, so if you like challenging and fun playshooter games, give it a go!
Last but not least, @mrclmb.ac.uk have also highlighted the work in this neat piece mrclmb.ac.uk/news-events/...
www.nature.com/articles/s41... An insighful study, leveraging MINFLUX to study chromatin dynamics by the @andersshansen.bsky.social lab @natsmb.nature.com . I am left wondering what if how we model chromatin with polymer simualtions needs rethinking, but surely many interesting findings here.
Neat recap also here news.mit.edu/2026/how-chr...
Subcellular mRNA localization relies on the recognition of cis-regulatory elements by trans-acting complexes, which mediate mRNA recruitment to the transport machineries. A study now defines the previ...
www.nature.com
Singh et al. combine cryo-electron microscopy and functional studies to reveal how a single protein complex selects diverse mRNAs for subcellular localization using a combination of shape, positional ...
www.nature.com
PDS5 proteins regulate genome organization by halting cohesin-mediated loop extrusion.
Wutz et al. show that PDS5 promotes NIPBL dissociation from cohesin, enabling CTCF
boundary formation and proper ...
Open Postdoc Position - Giant E3 ligases: mysterious mechanisms & non‑protein substrates. Interested? Join us to uncover how these molecular giants tag lipids, RNAs, sugars beyond proteins, on organelles and pathogens, to defend the cell. Details & Application here www.imp.ac.at/career/open-...
Happy to share our collaborative project with Stephane Marcand, on the protective role of Rap1 at telomeres. It turned out that our favorite protein, MRX, has the ability to measure telomere length, and activate response pathways when telomeres become too short. www.nature.com/articles/s41...
Enginefall is a player-driven crafting shooter set on colossal, post-apocalyptic megatrains. Start in the tail alone or with friends as you scavenge, craft, and build your way to First Class. Seize be...
Our story on RNA recognition by Egl-BicD is now published!
Also delighted to share the accompanying News & Views article by Florence Besse and Andres Ramos, which beautifully highlights the work.
Paper: www.nature.com/articles/s41...
News & Views: www.nature.com/articles/s41...
A collaborative study from the groups of Simon Bullock and Andrew Carter (Cell Biology and Structural Studies Divisions) has found a structural code that ex ...
Chromatin dynamics govern search times between DNA elements. Using integrated MINFLUX imaging, Mazzocca, Narducci, Grosse-Holz and colleagues track chromatin dynamics over seven orders of magnitude in...
www.nature.com
For the first time, MIT researchers measured the dynamics of chromatin movement over an extended period of time, ranging from the scale of microseconds to hours. The findings offer insight into how ge...
Singh et al. combine cryo-electron microscopy and functional studies to reveal how a single protein complex selects diverse mRNAs for subcellular localization using a combination of shape, positional ...
The hidden rules behind mRNA transport.
A collaborative study between @simonbullock11.bsky.social & @carter-lab.bsky.social’s groups has found a structural code that explains how cells selectively transport mRNAs.
Read more: mrclmb.ac.uk/news-events/...
#LMBNews @cellbiol-mrclmb.bsky.social 🧪
