Thrilled to see this work published. Thanks to helpful reviewer suggestions, there are some exciting new insights that were not in the preprint (particularly in Figure 4).
www.nature.com/articles/s41...
Singh et al. combine cryo-electron microscopy and functional studies to reveal how a single protein complex selects diverse mRNAs for subcellular localization using a combination of shape, positional ...
www.nature.com
Simon Bullock
It’s done!! Molecular architecture of the ciliary base in mammalian multiciliated cells! A study 13 years in the making 👴, thanks to collab with @stearnslab.bsky.social + @centriolelab.bsky.social & visionary work by @computingcaitie.bsky.social, who integrated native #cryoET with #XLMS & #UExM 🧪🧶🧬🔬
Come and work with us on #cryoEM of alpha-synuclein amyloid filaments from #Parkinsons disease! 🥳
fa-evzn-saasfaukgovprod1.fa.ocs.oraclecloud.com/hcmUI/Candid...
£42,694 per annum | Fixed-term for 3 years | Full-time | Closing date: 17 May 2026
Beautiful new study from @dyneinassembly.bsky.social lab on cilia recycling.
Always looking for ways to improve cryo-ET lamella quality. In last week’s #journalclub, we discussed what seems to be a promising and practical in-chamber sublimation approach for mitigating ice contamination and curtaining during lamella prep.
Preprint-- www.biorxiv.org/content/10.6...
Really proud to see this. Huge congratulations to @helenfoster.bsky.social on the Biochemical Society Early Career Award, well deserved!!
There are lots of exciting opportunities to join the in situ structural biology community at Leeds this Autumn - 2 studentships in the Cheney PhD program (astbury.leeds.ac.uk/cheney-phd/) and I am recruiting a PhD student and research assistant. Please share and send any future tomographers our way!
In our #journalclub, we looked at the cool new findings from Deng and colleagues, which show that the bacterial reverse transcriptase Drt3 chain B can synthesise poly(AC) DNA strands in the absence of a nucleic acid template, encoded by conserved surface amino acids.
www.science.org/doi/10.1126/...
New preprint from the lab, looking at how multiple different adaptors interact with dynein! Work led by @amicoennio.bsky.social.
Available now on BioRxiv: doi.org/10.64898/202...
Applications are open for 2 PhD student places. Closing date for applications is Thursday 26 June, 5pm. Interviews will be held on 9th July 2026. The Cheney Scholarship is a prestigious 4-year PhD pr...
Defense-associated reverse transcriptases (DRTs) are widespread bacterial anti-phage systems that use unconventional mechanisms of polynucleotide synthesis. We show that DRT3, which comprises two dist...
I am excited to share our most recent work collaborating with @centriolelab.bsky.social and @stearnslab.bsky.social to look at the ciliary base of mammalian multiciliated cells w/ cryo-ET, XL/MS, and U-ExM www.biorxiv.org/content/10.6...
Video
Our story on RNA recognition by Egl-BicD is now published!
Also delighted to share the accompanying News & Views article by Florence Besse and Andres Ramos, which beautifully highlights the work.
Paper: www.nature.com/articles/s41...
News & Views: www.nature.com/articles/s41...
Carter Lab
Carter Lab
Carter Lab
Carter Lab
Carter Lab
Carter Lab
Singh et al. combine cryo-electron microscopy and functional studies to reveal how a single protein complex selects diverse mRNAs for subcellular localization using a combination of shape, positional ...
I am delighted to be among this years winners awards from the Biochemical Society! The Early Career Award recognises the work I did during my PhD and postdoc, and hopefully signals a bright start for my new lab within the @astbury-bsl.bsky.social at the University of Leeds 💫
Caitie McCafferty
The hidden rules behind mRNA transport.
A collaborative study between @simonbullock11.bsky.social & @carter-lab.bsky.social’s groups has found a structural code that explains how cells selectively transport mRNAs.
Read more: mrclmb.ac.uk/news-events/...
#LMBNews @cellbiol-mrclmb.bsky.social 🧪
The hidden rules behind mRNA transport.
A collaborative study between @simonbullock11.bsky.social & @carter-lab.bsky.social’s groups has found a structural code that explains how cells selectively transport mRNAs.
Read more: mrclmb.ac.uk/news-events/...
#LMBNews @cellbiol-mrclmb.bsky.social 🧪
Happy to share our latest work spearheaded by super talented PhD student Muyang Ren now out as a bioRxiv preprint.
'Motile ciliophagy promotes ciliary recycling under stress'
www.biorxiv.org/content/10.6...
www.biorxiv.org
New preprint! We asked a simple question:
How do very different activating adaptors all activate dynein?
Turns out: same architecture, wildly different implementations 🧵👇
doi.org/10.64898/202...
doi.org
MRC Laboratory of Molecular Biology
MRC Laboratory of Molecular Biology
(GIRISH)MALI LAB
Helen Foster
Helen Foster
We are so proud of all our Biochemical Society 2027 Award winners. Visit our website to find out more about all of the deserving recipients #BiochemAwards 🧪
https://ow.ly/mZ6O50YIGo8
