Crazy things have been happening in cilia world, catch up on them in Caitie's new paper! 🪱
It’s done!! Molecular architecture of the ciliary base in mammalian multiciliated cells! A study 13 years in the making 👴, thanks to collab with @stearnslab.bsky.social + @centriolelab.bsky.social & visionary work by @computingcaitie.bsky.social, who integrated native #cryoET with #XLMS & #UExM 🧪🧶🧬🔬
Great opportunity to work in an exciting environment and a wonderful group!!
This is why I’m not allowed in the wet lab anymore 🥼 🕺. My technique is too effective! 🤪
#PILife #TeamTomo 🧪
This mesmerizing timelapse captures the nonstop motion inside an animal cell. Red/orange streaks are the growing ends of microtubules, tiny “highways” that can rapidly assemble and disassemble to move proteins & other molecules within the cell.
📸: Andy Moore, HHMI’s Janelia Research Campus
Big congratulations to our winners: Smilla-Maria Koy (1st), Chandrama Ghosh (2nd), and Anthony Rabaté (3rd)! Check out their breath-taking micrographs and the rest of the Top 15 entries in the stunning poster attached. The future of cilia research looks beautiful. 📸 #Cilia2027
I told you it was final 😉, now we celebrate 🎉
Video
Across scales from cells🦠 to atoms⚛️ – We reveal how anaerobic #bacteria break down very stable aromatic compounds found e.g. in oil spills 🛢️ #Bioremediation #TeamTomo 🧪 🧶🧬 🔬
Awesome collab with Lena, Matthias, @schullerjm.bsky.social @rnfr2d2.bsky.social @tomaspascoa.bsky.social @tamb-o.bsky.social
Video
And now it's out! Happy that PNAS selected for the cover this SEM image snapped by @samjlord.bsky.social, one of the most evocative visualizations of Euplotes that I have ever encountered.
www.pnas.org/doi/10.1073/...
Stay tuned for what is shaping up to be some fascinating follow-up in the lab...
Video
sofie.rec
Caitie McCafferty
Caitie McCafferty
EuroCilia2027
HHMI
Ben Engel
Ben Engel
Ben Engel
I am excited to share our most recent work collaborating with @centriolelab.bsky.social and @stearnslab.bsky.social to look at the ciliary base of mammalian multiciliated cells w/ cryo-ET, XL/MS, and U-ExM www.biorxiv.org/content/10.6...
I am excited to share our most recent work collaborating with @centriolelab.bsky.social and @stearnslab.bsky.social to look at the ciliary base of mammalian multiciliated cells w/ cryo-ET, XL/MS, and U-ExM www.biorxiv.org/content/10.6...
Video
Video
Now THIS one was quite the journey. I'm beyond happy to see this work out in the world 🥹
Huge congrats to @computingcaitie.bsky.social and also to @hugovdhoek.bsky.social and everyone else involved ♥️
with @centriolelab.bsky.social @stearnslab.bsky.social @cellarchlab.com
#Cilia #CryoET #TeamTomo
To supplement our cryo-ET and generate candidates for proteins that localize to different ciliary regions, we took a trip to the local butcher to pick up some cow trachea to build a mammalian multiciliated cell interactome using XL/MS (enjoy this vid of @cellarchlab.com shaking cilia off trachea)
Caitie McCafferty
Ben Larson
Caitie McCafferty
Video
Caitie McCafferty
What could be more exciting than watching Euplotes scurry around under the microscope? How about adding some raptorial predation by supergiant cannibal cells?
www.biorxiv.org/content/10.1...
Video by Vittorio Boscaro.
1/n
I am excited to share our most recent work collaborating with @centriolelab.bsky.social and @stearnslab.bsky.social to look at the ciliary base of mammalian multiciliated cells w/ cryo-ET, XL/MS, and U-ExM www.biorxiv.org/content/10.6...
Video
Video
Ben Larson
Caitie McCafferty
1/ Excited to share our preprint! 🥳
Degradation of aromatic compounds, including BTEX pollutants, requires highly endergonic aromatic ring reduction. Using #cryoEM and in situ #cryoET, we show how BCRII couples electron bifurcation modules in one giant redox machine
www.biorxiv.org/content/10.6...
