Happy to share our collaborative project with Stephane Marcand, on the protective role of Rap1 at telomeres. It turned out that our favorite protein, MRX, has the ability to measure telomere length, and activate response pathways when telomeres become too short. www.nature.com/articles/s41...
Val di Mello and Preda Rossa in Valtellina, Italy
We've got a new paper out! In collaboration with @stapleslab.bsky.social @cejkalab.bsky.social @lucyhjackson-j.bsky.social, we show that IFI16 binds to stalled replication forks, protects nascent DNA and mediates an inflammatory response to replication stress.
authors.elsevier.com/sd/article/S...
Sea of clouds is over central Switzerland today
Middle of January in central Switzerland, but very little snow. More for hiking than skiing…
After a week-long meeting and excellent science in the Netherlands, it is nice to be back in the mountains.
New paper in collaboration with @unterholznerlab.bsky.social @cejkalab.bsky.social IFI16 protects stalled replication forks.
www.sciencedirect.com/science/arti...
Interesting paper from Virginie Ropars and collegues about the architecture of WRN and KU interaction. Interestingly, WRN binds on the internal (end-distal) side of KU. Thanks for this interesting collaboration! @pietropichierri.bsky.social
www.nature.com/articles/s41...
Replication stress is a key driver of DNA damage and genome instability. Here, we report that replication stress induces an inflammatory response in t…
The WRN helicase helps to protect stalled DNA replication forks during replication stress, but its activation mechanism remains unclear. Here, the authors demonstrate that Ku binds and stimulates WRN ...
Dear Colleagues,
Delighted to share that our first lab paper is now published in Nature.!!! 😊😊😊
We identify a previously concealed “safety limit” in DNA replication program: cells intrinsically rate-limit PCNA via PAF15, shaping strand-specific and global replication dynamics.
👉 rdcu.be/e1bBt
Happy to share our new pre-print on the dependency of ALT-positive tumors on the DNA translocase SMARCAL1. Outstanding work of @angelotaglialatela.bsky.social in collaboration with the Min, Lazzerini Denchi and @cejkalab.bsky.social laboratories! www.biorxiv.org/content/10.6...
www.biorxiv.org
Nature - PCNA–PAF15 has a key role in determining replisome dynamics during genome replication and protecting against genome instability.
