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by @jimpick.com
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Interesting paper from Virginie Ropars and collegues about the architecture of WRN and KU interaction. Interestingly, WRN binds on the internal (end-distal) side of KU. Thanks for this interesting collaboration! @pietropichierri.bsky.social www.nature.com/articles/s41...
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Structural basis of Ku-mediated activation of WRN exonuclease activity - Nature Communications
The WRN helicase helps to protect stalled DNA replication forks during replication stress, but its activation mechanism remains unclear. Here, the authors demonstrate that Ku binds and stimulates WRN ...
www.nature.com
Petr Cejka