In natural systems, form often determines function. Check out how this model of BLTP3A exhibits the tube-like form that allows it to bridge membranes, and how its partner protein, LC3, docked here near the C-terminus, can serve to orient BLTP3A towards its intended site of action/lipid delivery.
Happy to share the latest from the lab, led by Daniel Alvarez, in collaboration with @lizconibear.bsky.social. In this AA-MD tour-de-force, we delve deep into the mechanism and energetics of lipid uptake by bridge-like lipid transfer proteins, and we learn a few interesting things along the way...
The Hanna lab is looking for an enthusiastic Research Technologist to join the team! 😊
You’ll help lead projects focused on organelle health & resilience to establish momentum in the lab. 🔬🥽
Job description and details can be found here: psu.wd1.myworkdayjobs.com/PSU_Staff/jo...
APPLICATION INSTRUCTIONS: CURRENT PENN STATE EMPLOYEE (faculty, staff, technical service, or student), please login to Workday to complete the internal application process. Please do not apply here, a...
Fantastic new work revealing mechanisms of pro-apoptotic signaling as a result of lysosomal dysfunction and subsequent DNA damage.
🚨 We’re hiring a postdoc! 🚨
Interested in lysosomes, Parkinson’s disease, cell biology, microscopy — or all of the above? Come work with us at the Bonet-Ponce Lab!
Reach out directly: [email protected]
Learn more: bonetponcelab.com
Let’s chat!
Vanni Lab at UNIFR, Switzerland
How do lysosomes rapidly adapt to membrane tension to avoid bursting? In this article, @laylanassar.bsky.social and I highlight discoveries from Angela Kim, Spencer Freeman and colleagues who show a role for TMEM63A, a mechanosensitive cation channel in protecting lysosomes doi.org/10.1083/jcb....
We’re located at Penn State University in lovely State College, PA.
More info about the research focus of the lab can be found here: sites.psu.edu/hannalab/
Recent @yale.edu research led by @adwolfe.bsky.social, Milind Singh & @dacolon.bsky.social reveals neurons' ability to store glycogen as a backup fuel ⛽️, keeping the brain running under stress — a process called “glycogen-dependent glycolytic plasticity” (GDGP).
Michael Hanna
Michael Hanna
Hely Rodriguez
doi.org
Nassar and Ferguson discuss work from Kim et al. showing that TMEM63A protects lysosomes from rupture by acting as a pressure relief valve when membrane te
Molecular insights into bulk lipid transport from structural studies of the bridge-like protein VPS13A complexed with the scramblase XKR1 www.biorxiv.org/content/10.6...
shawnferguson.bsky.social
Luis Bonet-Ponce
In eukaryotes, bridge-like lipid-transfer proteins (BLTPs) are central in mediating vesicle-independent lipid transfer between organelles. BLTPs span the cytosolic space between organelles at contact ...
The molecular mechanism of lipid uptake by membrane-anchored bridge-like lipid transfer proteins. https://www.biorxiv.org/content/10.1101/2025.08.01.668188v1
