IL-23 promotes a pro-inflammatory Th17 cell state by stabilizing RORγt and suppressing glucocorticoid receptor activity @cp-immunity.bsky.social @kuchroolab.bsky.social @harvardmed.bsky.social
www.cell.com/immunity/ful...
2⃣ IL-23 switches on a pro-inflammatory Th17 state by stabilizing RoRgt & impairing GC sensing, via epigenetic & transcriptional regulation.
#AnaAndersonLab #YosefLab
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www.cell.com/immunity/ful...
Early-life interventions & airway microbiome
Nasal microbial gene atlas in infants w/cystic fibrosis. Hypertonic saline inhalation reshapes microbiome, selects salt-tolerant H. influenzae & ⬆️transporters linked to antibiotic tolerance @thexavierlab.bsky.social
www.cell.com/cell-host-mi...
What the nose knows of cystic fibrosis microbes and hypertonic saline
Bouzek Previews work by @thexavierlab.bsky.social presenting microbial gene atlas of nasopharyngeal swabs in infants w/cystic fibrosis & healthy controls & IDing impacts of clinical interventions
www.cell.com/cell-host-mi...
These findings could help address steroid resistance of Th17 cells frequently seen in the clinic that constrains the efficacy of this mainstay of treatment for autoimmune flares.
@genelayinstitute.bsky.social @mgbresearch.bsky.social
@harvardmed.bsky.social @broadinstitute.org
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