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💫Back2back papers in @cp-immunity.bsky.social led by #DandanYang: multi-omics studies reveal how the gluococorticoid (GC) pathway restrains Th17 cell pathogenicity. 1️⃣ GC steroid synthesis & sensing maintain the homeostatic state of Th17 cells. #AnaAndersonLab 1/3 🧵 www.cell.com/immunity/ful...
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Th17 cells can either preserve homeostasis or drive inflammation in tissues; however, the mechanisms that maintain homeostatic phenotypes are not well defined. Yang et al. uncover a cell-intrinsic glu...
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A cell-intrinsic glucocorticoid biosynthesis and sensing circuit maintains a homeostatic Th17 cell state
Kuchroo Lab