Online now: A cell-intrinsic glucocorticoid biosynthesis and sensing circuit maintains a homeostatic Th17 cell state
Th17 cells can either preserve homeostasis or drive inflammation in tissues; however, the mechanisms that maintain homeostatic phenotypes are not well defined. Yang et al. uncover a cell-intrinsic glucocorticoid circuit and the underlying gene network by which it maintains homeostasis in Th17 cells. They find that TGF-β1 can reverse the glucocorticoid resistance exhibited by both murine and human inflammatory Th17 cells.
