Immunology-focused research in cancer & aging | understanding immune evasion & resilience | improving health outcomes. 🔗 https://genelayinstitute.org/
#Brigham&WomensHospital #MassGeneralHospital @HarvardMed.bsky.social
The Gene Lay Institute of Immunology and Inflammation
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What the nose knows of cystic fibrosis microbes and hypertonic saline
Bouzek Previews work by @thexavierlab.bsky.social presenting microbial gene atlas of nasopharyngeal swabs in infants w/cystic fibrosis & healthy controls & IDing impacts of clinical interventions
www.cell.com/cell-host-mi...
Early-life interventions & airway microbiome
Nasal microbial gene atlas in infants w/cystic fibrosis. Hypertonic saline inhalation reshapes microbiome, selects salt-tolerant H. influenzae & ⬆️transporters linked to antibiotic tolerance @thexavierlab.bsky.social
www.cell.com/cell-host-mi...
IL-23 promotes a pro-inflammatory Th17 cell state by stabilizing RORγt and suppressing glucocorticoid receptor activity @cp-immunity.bsky.social @kuchroolab.bsky.social @harvardmed.bsky.social
www.cell.com/immunity/ful...
In this issue of Cell Host & Microbe, Steinberg et al. present a microbial gene atlas
of nasopharyngeal swabs in infants with cystic fibrosis and healthy controls using
shotgun metagenomic sequencing....
www.cell.com
Steinberg et al. generated an infant nasal microbial gene atlas using samples from
infants with and without cystic fibrosis. Frequent hypertonic saline inhalation reshapes
airway microbiome function, ...
These findings could help address steroid resistance of Th17 cells frequently seen in the clinic that constrains the efficacy of this mainstay of treatment for autoimmune flares.
@genelayinstitute.bsky.social @mgbresearch.bsky.social
@harvardmed.bsky.social @broadinstitute.org
3/3
2⃣ IL-23 switches on a pro-inflammatory Th17 state by stabilizing RoRgt & impairing GC sensing, via epigenetic & transcriptional regulation.
#AnaAndersonLab #YosefLab
2/3
www.cell.com/immunity/ful...
💫Back2back papers in @cp-immunity.bsky.social led by #DandanYang: multi-omics studies reveal how the gluococorticoid (GC) pathway restrains Th17 cell pathogenicity.
1️⃣ GC steroid synthesis & sensing maintain the homeostatic state of Th17 cells.
#AnaAndersonLab
1/3 🧵
www.cell.com/immunity/ful...
Cell Host & Microbe
Cell Host & Microbe
Online now: A cell-intrinsic glucocorticoid biosynthesis and sensing circuit maintains a homeostatic Th17 cell state
Waggoner Lab
Online now: Interleukin 23 promotes a pro-inflammatory Th17 cell state by stabilizing RORγt and suppressing glucocorticoid receptor activity
Inhibitory receptor agonists: Emerging strategies in immune modulation. Review from Kieran R. Adam and Aamir Suhail @vignalilab.bsky.social @kuchroolab.bsky.social: rupress.org/jem/article/...
📘 From #Inflammation Resolution 2026: rupress.org/jem/collecti...
#KSInflammation26
Excited to share this new preprint from a large collaborative effort using #exome + #genome sequencing, moving beyond GWAS to implicate 68 genes in #IBD through rare protein-coding variation.
bit.ly/43h72GA
@broadinstitute.org
@mgbresearch.bsky.social
Kuchroo Lab
Kuchroo Lab
Kuchroo Lab
Immunity
Inflammatory bowel disease (IBD) is a chronic immune-mediated disorder of the gastrointestinal tract whose genetic basis is only partly resolved because most risk variants identified by genome-wide as...
